N‐Substituted pyrimidinethione and acetophenone derivatives as a new therapeutic approach in diabetes
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DOI: 10.1002/ardp.202000075
Abstract: In this study, compounds with 4‐hydroxybutyl, 4‐phenyl, 5‐carboxylate, and pyrimidine moieties were determined as α‐glycosidase inhibitors. N‐Substituted pyrimidinethione and acetophenone derivatives (A1–A5, B1–B11, and C1–C11) were good inhibitors of the α‐glycosidase enzyme, with Ki values… read more here.
Keywords: substituted pyrimidinethione; pyrimidinethione; acetophenone derivatives; derivatives new ... See more keywords
In vitro inhibitory effects of some acetophenone derivatives on some metabolic enzymes and molecular docking
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DOI: 10.1002/ardp.202000210
Abstract: In this study, the acetophenone derivatives 1–6 were found to be effective inhibitor molecules for α‐glycosidase, human carbonic anhydrases I and II (hCA I/II), and acetylcholinesterase (AChE), with Ki values in the range of 167.98 ± 25.06… read more here.
Keywords: inhibitory effects; vitro inhibitory; acetophenone derivatives; pdb ... See more keywords
Novel rearranged acetophenone derivatives possessing diverse architectures from the leaves of Melicope ptelefolia
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DOI: 10.1016/j.tet.2019.130784
Abstract: Abstract Melicolones C–K (1–9), nine acetophenone derivatives with three unprecedented architectures, were characterized from the leaves of Melicope ptelefolia. Among them, melicolone C (1) was a novel acetophenone analogue possessing a highly rearranged spiro skeleton.… read more here.
Keywords: acetophenone; leaves melicope; rearranged acetophenone; acetophenone derivatives ... See more keywords