Kinetic, spectral, and structural studies of the slow-binding inhibition of the Escherichia coli dihydrodipicolinate synthase by 2, 4-oxo-pentanoic acid.
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DOI: 10.1016/j.abb.2021.108819
Abstract: Dihydrodipicolinate synthase (DHDPS) catalyzes the first step in the biosynthetic pathway for production of l-lysine in bacteria and plants. The enzyme has received interest as a potential drug target owing to the absence of the… read more here.
Keywords: pyruvate; pentanoic acid; oxo pentanoic; dihydrodipicolinate synthase ... See more keywords