Synthesis, computational studies and biological evaluation of new 1-acetyl-3-aryl thiourea derivatives as potent cholinesterase inhibitors
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DOI: 10.1007/s00044-017-1829-6
Abstract: A new series of 1-acetyl-3-aryl thioureas (3f1–15) was synthesized by the reaction of acetyl isothiocyanate with a variety of suitably substituted aromatic anilines. The acetyl isothiocyanate was freshly prepared by reaction of corresonding acid chloride… read more here.
Keywords: inhibitor; acetyl; acetylcholinesterase; acetyl aryl ... See more keywords
Synthesis, In Vitro Evaluation and Molecular Docking of the 5-Acetyl-2-aryl-6-hydroxybenzo[b]furans against Multiple Targets Linked to Type 2 Diabetes
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DOI: 10.3390/biom10030418
Abstract: The 5-acetyl-2-aryl-6-hydroxybenzo[b]furans 2a–h have been evaluated through in vitro enzymatic assay against targets which are linked to type 2 diabetes (T2D), namely, α-glucosidase, protein tyrosine phosphatase 1B (PTP1B) and β-secretase. These compounds have also been… read more here.
Keywords: aryl hydroxybenzo; acetyl aryl; hydroxybenzo furans; targets linked ... See more keywords