Improvement of acetyl-CoA supply and glucose utilization increases l-leucine production in Corynebacterium glutamicum.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology journal"
DOI: 10.1002/biot.202100349
Abstract: BACKGROUND l-Leucine is one of important essential amino acids with multiple industrial applications, whose market requirements cannot be met because of the lower productivity. MAIN METHODS AND MAJOR RESULTS In this study, a strain of… read more here.
Keywords: acetyl; coa supply; acetyl coa; glutamicum ... See more keywords
Enhanced isoprenoid production from xylose by engineered Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26369
Abstract: Saccharomyces cerevisiae has limited capabilities for producing fuels and chemicals derived from acetyl‐CoA, such as isoprenoids, due to a rigid flux partition toward ethanol during glucose metabolism. Despite numerous efforts, xylose fermentation by engineered yeast… read more here.
Keywords: utilization; saccharomyces cerevisiae; production; engineered yeast ... See more keywords
Mitochondrial Acetyl‐CoA Synthetase 3 is Biosignature of Gastric Cancer Progression
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1295
Abstract: Cholesterol affects cancer progression, and acetyl‐CoA is the primary cholesterogenesis substrate. The previous work has defined cholesterol bioflux via lipoprotein/receptor route is the gastric cancer (GCa) prognosis biosignature. The prognosis importance of acetyl‐CoA to cholesterogenesis… read more here.
Keywords: prognosis; progression; gca; cancer ... See more keywords
Acetyl‐CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30097
Abstract: Pharmacologic inhibition of acetyl‐CoA carboxylase (ACC) enzymes, ACC1 and ACC2, offers an attractive therapeutic strategy for nonalcoholic fatty liver disease (NAFLD) through simultaneous inhibition of fatty acid synthesis and stimulation of fatty acid oxidation. However,… read more here.
Keywords: hepatic insulin; acetyl coa; inhibition; insulin resistance ... See more keywords
Comments on “Inhibition of the ketolytic acetyl CoA supply to tumors could be their ‘Achilles heel’”
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Cancer"
DOI: 10.1002/ijc.33017
Abstract: Dear editor, In an interesting letter published recently in this journal, Drs Israël and Schwartz hypothesize that the breakdown of ketone bodies is a tumor cell's “unique source of mitochondrial acetyl CoA”. They propose to… read more here.
Keywords: tumor; coa; acetyl coa; cell ... See more keywords
Abnormal concentrations of acetylated amino acids in cerebrospinal fluid in acetyl‐CoA transporter deficiency
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12549
Abstract: Acetyl‐CoA transporter 1 (AT‐1) is a transmembrane protein which regulates influx of acetyl‐CoA from the cytosol to the lumen of the endoplasmic reticulum and is therefore important for the posttranslational modification of numerous proteins. Pathological… read more here.
Keywords: acetylated amino; amino acids; acetyl coa; coa transporter ... See more keywords
Enhancement of acetyl-CoA by acetate co-utilization in recombinant Lactococcus lactis cultures enables the production of high molecular weight hyaluronic acid
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-09987-6
Abstract: The molecular weight of hyaluronic acid (HA) is a critical property which determines its usage in various biomedical applications. This study investigates the correlation between the availability of a critical cofactor, acetyl-CoA, the concentration of… read more here.
Keywords: lactis; molecular weight; acetyl coa; coa ... See more keywords
Constitutive and Chloroplast Targeted Expression of Acetyl-CoA Carboxylase in Oleaginous Microalgae Elevates Fatty Acid Biosynthesis
Sign Up to like & getrecommendations! Published in 2018 at "Marine Biotechnology"
DOI: 10.1007/s10126-018-9841-5
Abstract: Photosynthetic microalgae are of burgeoning interest in the generation of commercial bioproducts. Microalgae accumulate high lipid content under adverse conditions, which in turn compromise their growth and hinder their commercial potential. Hence, it is necessary… read more here.
Keywords: acetyl coa; microalgae; fatty acid; coa carboxylase ... See more keywords
Nitrogen starvation–induced oxidative stress relieves PII-mediated inhibition of acetyl-CoA carboxylase (ACCase) activity and signals enhanced lipid synthesis in Synechococcus PCC 7942
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Phycology"
DOI: 10.1007/s10811-020-02316-9
Abstract: The present study shows the existence of P II -acetyl-CoA carboxylase interaction in the cyanobacterium Synechococcus sp. PCC 7942 and the possible adverse impact of nitrogen starvation on this interaction. The in silico and in… read more here.
Keywords: carboxylase; acetyl coa; coa carboxylase; nitrogen starvation ... See more keywords
FABP7 Regulates Acetyl-CoA Metabolism Through the Interaction with ACLY in the Nucleus of Astrocytes
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Neurobiology"
DOI: 10.1007/s12035-020-02057-3
Abstract: Fatty acid binding protein 7 (FABP7) is an intracellular fatty acid chaperon that is highly expressed in astrocytes, oligodendrocyte-precursor cells, and malignant glioma. Previously, we reported that FABP7 regulates the response to extracellular stimuli by… read more here.
Keywords: coa metabolism; fabp7 regulates; coa; interaction ... See more keywords
Different effects of acetyl-CoA carboxylase inhibitor TOFA on airway inflammation and airway resistance in a mice model of asthma
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological Reports"
DOI: 10.1007/s43440-019-00027-8
Abstract: Background and objective Acetyl CoA carboxylase (ACC) regulates the differentiation of Th1, Th2, Th17 cells and Treg cells, which play a critical role in airway inflammation of asthma. Here we investigated the role of ACC… read more here.
Keywords: tofa; airway inflammation; expression; acetyl coa ... See more keywords