Role of Transporters and Enzymes in Metabolism and Distribution of 4-Chlorokynurenine (AV-101)
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DOI: 10.1021/acs.molpharmaceut.3c00700
Abstract: 4-Chlorokynurenine (4-Cl-KYN, AV-101) is a prodrug of a NMDA receptor antagonist and is in clinical development for potential CNS indications. We sought to further understand the distribution and metabolism of 4-Cl-KYN, as this information might… read more here.
Keywords: acetyl kyn; distribution; chlorokynurenine; drug ... See more keywords