d‐amino acid modification protects N‐Acetyl‐seryl‐aspartyl‐lysyl‐proline from physiological hydroxylation and increases its antifibrotic effects on hepatic fibrosis
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DOI: 10.1002/iub.2037
Abstract: N‐Acetyl‐seryl‐aspartyl‐lysyl‐proline (Ac‐SDKP) is a critical negative regulator of fibrosis development in the liver. However, its extremely short half‐life in vivo greatly compromises its potential applications. Here, we report an Ac‐SDKP analog peptide with d‐amino acid… read more here.
Keywords: acetyl seryl; seryl aspartyl; amino acid; fibrosis ... See more keywords
Renal Protective Effects of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) in Obese Rats on a High-Salt Diet
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DOI: 10.1093/ajh/hpy052
Abstract: Abstract BACKGROUND Obesity is a public health problem, associated with salt sensitive hypertension, kidney inflammation, and fibrosis. N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a tetra peptide with anti-inflammatory and anti-fibrotic properties. However, its effect on preventing kidney damage… read more here.
Keywords: inflammation fibrosis; acetyl seryl; sdkp; salt diet ... See more keywords