Reshaping acetylated peptide selectivity between human BET Brd2 bromodomains BD-I and BD-II in glioblastoma by rationally grafting secondary anchor residues.
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DOI: 10.4149/gpb_2017063
Abstract: Selective inhibition of BET Brd2 BD-I and BD-II bromodomains is expected to elicit subtle pharmacological difference in anti-glioblastoma therapy. Here, structural basis and energetic property underlying the selective interaction of acetylated peptide ligands with Brd2… read more here.
Keywords: secondary anchor; anchor residues; acetylated peptide; peptide selectivity ... See more keywords