Programmed ubiquitin acetylation using genetic code expansion reveals altered ubiquitination patterns
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13702
Abstract: Ubiquitination is a post‐translational modification (PTM) capable of being regulated by other PTMs, including acetylation. However, the biological consequences of acetylated ubiquitin (acUb) variants are poorly understood, due to their transient nature in vivo and… read more here.
Keywords: code expansion; acetylation; ubiquitination patterns; using genetic ... See more keywords
Harnessing the TAF1 Acetyltransferase for Targeted Acetylation of the Tumor Suppressor p53
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202413377
Abstract: Pharmacological reactivation of the tumor suppressor p53 remains a key challenge for the treatment of cancer. Acetylation Targeting Chimera (AceTAC), a novel technology is previously reported that hijacks lysine acetyltransferases p300/CBP to acetylate the p53Y220C… read more here.
Keywords: suppressor p53; tumor suppressor; p53; acetylation ... See more keywords
Restoring Histone Acetylation Accelerates Diabetic Wound Repair by Improving the Spatiotemporal Dynamics of Macrophages.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202504920
Abstract: Dysregulation of macrophage populations at the wound site is responsible for the non‐healing state of chronic wounds. The underlying mechanisms in diabetic conditions at single cell resolution and therapeutic advances remain, however, largely unexplored. Here,… read more here.
Keywords: chronic wounds; repair; diabetic conditions; macrophage ... See more keywords
Acetylation of the Mitochondrial Chaperone GRP75 Governs ER-Mitochondrial Calcium Homeostasis and Hepatocyte Insulin Resistance.
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DOI: 10.1002/advs.202508991
Abstract: Overnutrition exacerbates insulin resistance (IR) and is linked to excessive mitochondrial protein acetylation. However, the molecular mechanism by which mitochondrial protein acetylation influences hepatic IR remains incompletely elucidated. To investigate this biology, GCN5L1 liver knockout… read more here.
Keywords: insulin resistance; calcium; grp75; acetylation ... See more keywords
An enriched environment improves maternal sleep deprivation-induced cognitive deficits and synaptic plasticity via hippocampal histone acetylation.
Sign Up to like & getrecommendations! Published in 2023 at "Brain and behavior"
DOI: 10.1002/brb3.3018
Abstract: INTRODUCTION Growing evidence clearly demonstrates that maternal rodents exposure to sleep deprivation (SD) during late pregnancy impairs learning and memory in their offspring. Epigenetic mechanisms, particularly histone acetylation, are known to be involved in synaptic… read more here.
Keywords: memory; synaptic plasticity; acetylation; histone acetylation ... See more keywords
Beyond Histones: Unveiling the Functional Roles of Protein Acetylation in Prokaryotes and Eukaryotes
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biology International"
DOI: 10.1002/cbin.70055
Abstract: Lysine acetylation plays a crucial role in cellular processes and is found across various evolutionary organisms. Recent advancements in proteomic techniques revealed the presence of acetylation in thousands of non-histone proteins. Here, we conducted extensive… read more here.
Keywords: cellular processes; lysine acetylation; histones unveiling; unveiling functional ... See more keywords
Effect of a solvent‐free acetylation treatment on reinforcements permeability and tensile behaviour of flax/epoxy and flax/wood fibre/epoxy composites
Sign Up to like & getrecommendations! Published in 2017 at "Canadian Journal of Chemical Engineering"
DOI: 10.1002/cjce.22777
Abstract: Acetylation is a common way to enhance interfacial adhesion between natural fibres and polymeric matrices in composites. This work investigates the effect of a solvent-free environmentally friendly acetylation treatment of short flax and kraft fibres… read more here.
Keywords: flax; acetylation; treatment; permeability ... See more keywords
Recombinant Monoclonal Antibodies for Detecting the Tubulin Post-Translational Modifications Glutamylation and Lysine-40 Acetylation.
Sign Up to like & getrecommendations! Published in 2025 at "Cytoskeleton"
DOI: 10.1002/cm.70011
Abstract: Post-translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine-40 (K40) on α-tubulin… read more here.
Keywords: translational modifications; glutamylation; tubulin; post translational ... See more keywords
Rutin increases alpha-tubulin acetylation via histone deacetylase 6 inhibition.
Sign Up to like & getrecommendations! Published in 2022 at "Drug development research"
DOI: 10.1002/ddr.21927
Abstract: Microtubules are dynamic cytoskeletal filaments composed of alpha- (α) and beta (β)-tubulin proteins. α-tubulin proteins are posttranslationally acetylated, and loss of acetylation is associated with axonal transport defects, a common alteration contributing to the pathomechanisms… read more here.
Keywords: tubulin acetylation; increases alpha; inhibition; rutin increases ... See more keywords
miR‐34a Targets HDAC1‐Regulated H3K9 Acetylation on Lipid Accumulation Induced by Homocysteine in Foam Cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26126
Abstract: Hyperhomocysteinemia (HHcy) promotes atherogenesis by modification of histone acetylation patterns and regulation of miRNA expression while the underlying molecular mechanisms are not well known. In this study, we investigated the effects of homocysteine (Hcy) on… read more here.
Keywords: accumulation; acetylation; mir 34a; expression ... See more keywords
Coordinated expression of p300 and HDAC3 upregulates histone acetylation during dentinogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29470
Abstract: Cellular differentiation is caused by highly controlled modifications in the gene expression but rarely involves a change in the DNA sequence itself. Histone acetylation is a major epigenetic factor that adds an acetyl group to… read more here.
Keywords: dentinogenesis; histone acetylation; acetylation; odontoblast differentiation ... See more keywords