Regulated acetylation and deacetylation of H4 K16 is essential for efficient NER in Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2018 at "DNA repair"
DOI: 10.1016/j.dnarep.2018.09.009
Abstract: Acetylation status of H4 K16, a residue in the histone H4 N-terminal tail plays a unique role in regulating chromatin structure and function. Here we show that, during UV-induced nucleotide excision repair H4 K16 gets… read more here.
Keywords: acetylation deacetylation; acetylation; k16 mutants; ner ... See more keywords
Acetylation and deacetylation in cancer stem-like cells
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DOI: 10.18632/oncotarget.19167
Abstract: Cancer stem-like cell (CSC) model has been established to investigate the underlying mechanisms of tumor initiation and progression. The imbalance between acetylation and deacetylation of histone or non-histone proteins, one of the important epigenetic modification… read more here.
Keywords: cancer; acetylation deacetylation; stem like; cancer stem ... See more keywords
Targeted Cancer Therapy Based on Acetylation and Deacetylation of Key Proteins Involved in Double-Strand Break Repair
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DOI: 10.2147/cmar.s346052
Abstract: Abstract DNA double-strand breaks (DSBs) play an important role in promoting genomic instability and cell death. The precise repair of DSBs is essential for maintaining genome integrity during cancer progression, and inducing genomic instability or… read more here.
Keywords: acetylation deacetylation; cancer; double strand; repair ... See more keywords
The Role of Post-Translational Acetylation and Deacetylation of Signaling Proteins and Transcription Factors after Cerebral Ischemia: Facts and Hypotheses
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DOI: 10.3390/ijms22157947
Abstract: Histone deacetylase (HDAC) and histone acetyltransferase (HAT) regulate transcription and the most important functions of cells by acetylating/deacetylating histones and non-histone proteins. These proteins are involved in cell survival and death, replication, DNA repair, the… read more here.
Keywords: acetylation deacetylation; transcription factors; acetylation; role ... See more keywords
Ku70 N-terminal lysines acetylation/deacetylation is required for radiation-induced DNA-double strand breaks repair.
Sign Up to like & getrecommendations! Published in 2018 at "Neoplasma"
DOI: 10.4149/neo_2018_171020n673
Abstract: Ku70 protein in hetero-trimeric complex with Ku80 and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) represents a critical component of the nonhomologous-end-joining (NHEJ), the major machinery of DSBs repair in mammalian cells. It has been previously… read more here.
Keywords: acetylation deacetylation; acetylation; ku70; dna ... See more keywords