Allyl isothiocyanate regulates lysine acetylation and methylation marks in an experimental model of malignant melanoma
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DOI: 10.1007/s00394-019-01925-6
Abstract: Objective(s) Isothiocyanates (ITCs) are biologically active plant secondary metabolites capable of mediating various biological effects including modulation of the epigenome. Our aim was to characterize the effect of allyl isothiocyanate (AITC) on lysine acetylation and… read more here.
Keywords: melanoma; methylation marks; malignant melanoma; lysine acetylation ... See more keywords
Sulforaphane and iberin are potent epigenetic modulators of histone acetylation and methylation in malignant melanoma
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DOI: 10.1007/s00394-020-02227-y
Abstract: Objective(s) Growing evidence supports that isothiocyanates exert a wide range of bioactivities amongst of which is their capacity to interact with the epigenetic machinery in various cancers including melanoma. Our aim was to characterise the… read more here.
Keywords: melanoma; sulforaphane iberin; acetylation methylation; malignant melanoma ... See more keywords
Benzyl and phenethyl isothiocyanates as promising epigenetic drug compounds by modulating histone acetylation and methylation marks in malignant melanoma
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DOI: 10.1007/s10637-021-01127-0
Abstract: Melanoma is an aggressive skin cancer with increasing incidence rates globally. On the other hand, isothiocyanates are derived from cruciferous vegetables and are known to exert a wide range of anti-cancer activities including, among others,… read more here.
Keywords: melanoma; acetylation methylation; histone; malignant melanoma ... See more keywords
Histone Acetylation and Methylation Underlie Oligodendroglial and Myelin Susceptibility in Schizophrenia
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DOI: 10.3389/fncel.2022.823708
Abstract: Schizophrenia is a complex neuropsychiatric disorder affected by both genetic and epigenetic factors. Except for neuronal dysfunction, oligodendroglial abnormalities also contribute to the disease pathogenesis, characterized by a robust dysregulation of oligodendrocyte and myelin related… read more here.
Keywords: histone acetylation; myelin; histone; acetylation methylation ... See more keywords