Abstract 328: Acetylation regulates the oncogenic functions of PRMT5
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-328
Abstract: Protein arginine methyltransferase 5 (PRMT5) is an enzyme responsible for symmetric arginine methylation, which governs multiple crucial cellular events. PRMT5 expression and activity are dysregulated in many malignancies. PRMT5 dynamically shuttles between the cytosol and… read more here.
Keywords: regulates oncogenic; acetylation; functions prmt5; acetylation regulates ... See more keywords
CPT2 K79 acetylation regulates platelet life span
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2021006687
Abstract: Key Points CPT2 K79 acetylation caused by NAD+ exhaustion and Sirt3 dysfunction resulted in LCAC accumulation and platelet damage. Blocking acylcarnitine generation with AMPK or CPT1 inhibitors, Sirt3 agonists, and antioxidants retarded platelet storage lesion. read more here.
Keywords: regulates platelet; cpt2 k79; acetylation regulates; k79 acetylation ... See more keywords