Cellular substrate limitations of lysine acetylation turnover by sirtuins investigated with engineered futile cycle enzymes.
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DOI: 10.1016/j.ymben.2018.04.022
Abstract: Metabolic activity and epigenetic regulation of gene expression are intimately coupled. The mechanisms linking the two are incompletely understood. Sirtuins catalyse the removal of acetyl groups from lysine side chains of proteins using NAD+ as… read more here.
Keywords: sirtase; turnover sirtuins; acetylation; acetylation turnover ... See more keywords