SELECTIVE ACTIONS OF INSECTICIDES ON DESENSITIZING and NON-DESENSITIZING NICOTINIC ACETYLCHOLINE RECEPTORS IN COCKROACH (Periplaneta americana) NEURONS.
Sign Up to like & getrecommendations! Published in 2021 at "Pest management science"
DOI: 10.1002/ps.6396
Abstract: BACKGROUND Insect desensitizing nicotinic acetylcholine (nAChD) receptors are desensitized by low concentrations of agonists, including neonicotinoid insecticides, but are essentially insensitive to spinosyns, while non-desensitizing nicotinic acetylcholine (nAChN) receptors are selectively activated by spinosyns and… read more here.
Keywords: acetylcholine; desensitizing nicotinic; nicotinic acetylcholine; non desensitizing ... See more keywords
Reduced acetylcholine and elevated muscarinic receptor 2 in duodenal mucosa contribute to the impairment of mucus secretion in 6-hydroxydopamine-induced Parkinson's disease rats.
Sign Up to like & getrecommendations! Published in 2021 at "Cell and tissue research"
DOI: 10.1007/s00441-021-03515-7
Abstract: Patients with Parkinson's disease (PD) have a higher incidence rate of duodenal ulcers. The mucus barrier provides the first line of defense for duodenal mucosal protection. However, it is unknown whether duodenal mucus secretion is… read more here.
Keywords: acetylcholine; duodenal mucosa; mucus secretion; mucus ... See more keywords
Influence of Membrane Receptor Lateral Diffusion on the Short-Term Depression of Acetylcholine-Induced Current in Helix Neurons
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0475-3
Abstract: We have studied how various drugs increasing the rate of nicotinic acetylcholine receptors (nAChRs) lateral diffusion affect the depression of ACh-induced current in land snail Helix lucorum neurons responsible for defensive behavior. The acetylcholine (ACh)… read more here.
Keywords: nachrs lateral; depression; diffusion; acetylcholine ... See more keywords
Inhibition of basal and amphetamine-stimulated extracellular signal-regulated kinase (ERK) phosphorylation in the rat forebrain by muscarinic acetylcholine M4 receptors
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2018.03.019
Abstract: The mitogen-activated protein kinase (MAPK), especially its extracellular signal-regulated kinase (ERK) subfamily, is a group of kinases enriched in the mammalian brain. While ERK is central to cell signaling and neural activities, the regulation of… read more here.
Keywords: amphetamine; acetylcholine; erk phosphorylation; kinase ... See more keywords
Endocytic sorting and downregulation of the M2 acetylcholine receptor is regulated by ubiquitin and the ESCRT complex
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107828
Abstract: Cholinergic dysfunction plays a critical role in a number of disease states, and the loss of functional muscarinic acetylcholine receptors plays a key role in disease pathogenesis. Therefore, preventing receptor downregulation would maintain functional receptor… read more here.
Keywords: sorting downregulation; acetylcholine; endocytic sorting; muscarinic receptor ... See more keywords
Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2017.10.024
Abstract: Irreversible inhibition of the acetylcholine esterase upon intoxication with organophosphorus compounds leads to an accumulation of acetylcholine in the synaptic cleft and a subsequent desensitization of nicotinic acetylcholine receptors which may ultimately result in respiratory… read more here.
Keywords: acetylcholine; nicotinic acetylcholine; bispyridinium compound; binding sites ... See more keywords
Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2017.12.005
Abstract: Irreversible inhibition of acetylcholinesterase (AChE) resulting in accumulation of acetylcholine and overstimulation of muscarinic and nicotinic receptors accounts for the acute toxicity of organophosphorus compounds (OP). Accordingly, the mainstay pharmacotherapy against poisoning by OP comprises… read more here.
Keywords: bispyridinium compounds; acetylcholine receptors; acetylcholine; nicotinic acetylcholine ... See more keywords
Exploring the Relationship between Nicotinic Acetylcholine Receptor Ligand Size, Efficiency, Efficacy, and C-Loop Opening.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.7b00152
Abstract: Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels mediating fundamental physiological activities in the nervous system and have become important targets for drug design. For a long time, the acetylcholine binding protein (AChBP) has been… read more here.
Keywords: acetylcholine; ligand; size; ligand size ... See more keywords
Peptide Inhibitors of the α-Cobratoxin–Nicotinic Acetylcholine Receptor Interaction
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.0c01202
Abstract: Venomous snakebites cause >100 000 deaths every year, in many cases via potent depression of human neuromuscular signaling by snake α-neurotoxins. Emergency therapy still relies on antibody-based antivenom, hampered by poor access, frequent adverse reactions,… read more here.
Keywords: acetylcholine; inhibitors cobratoxin; nicotinic acetylcholine; cobratoxin nicotinic ... See more keywords
Structural Biology-Guided Design, Synthesis, and Biological Evaluation of Novel Insect Nicotinic Acetylcholine Receptor Orthosteric Modulators.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01767
Abstract: The development of novel and safe insecticides remains an important need for a growing world population to protect crops and animal and human health. New chemotypes modulating the insect nicotinic acetylcholine receptors have been recently… read more here.
Keywords: design synthesis; synthesis biological; nicotinic acetylcholine; insect nicotinic ... See more keywords
Dual-Ionomer-Based Device: Acetylcholine Transport and Nonenzymatic Sensing.
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DOI: 10.1021/acsami.0c13725
Abstract: The malfunctioning in the release of acetylcholine (ACh+), leading to consequential damages in the neural system, has become an impulsion for the development of numerous progressive transport and detection gadgets. However, several challenges, such as… read more here.
Keywords: based device; acetylcholine; ionomer based; transport ... See more keywords