Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor
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DOI: 10.1002/cmdc.201800325
Abstract: A novel series of 30 symmetric bispyridinium and related N‐heteroaromatic bisquaternary salts with a propane‐1,3‐diyl linker was synthesized and characterized for their binding affinity at the MB327 binding site of nicotinic acetylcholine receptor (nAChR) from… read more here.
Keywords: series; acetylcholine receptor; nicotinic acetylcholine; mb327 ... See more keywords
Unraveling individual host–guest interactions in molecular recognition from first principles quantum mechanics: Insights into the nature of nicotinic acetylcholine receptor agonist binding
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.26454
Abstract: Drug binding to a protein target is governed by a complex pattern of noncovalent interactions between the ligand and the residues in the protein's binding pocket. Here we introduce a generally applicable, parameter‐free, computational method… read more here.
Keywords: guest interactions; nicotinic acetylcholine; host guest; molecular recognition ... See more keywords
IC/BPS‐associated alterations of M2 and M3 muscarinic acetylcholine receptor trafficking in human detrusor
Sign Up to like & getrecommendations! Published in 2019 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.24087
Abstract: To explore caveolae‐ and clathrin‐mediated internalization of muscarinic M2 and M3 receptors, recycling and degradation in formalin‐fixed paraffin‐embedded detrusor sections; to study alterations possibly involved in the pathophysiology of the bladder functional disorder, interstitial cystitis/bladder… read more here.
Keywords: detrusor; alterations muscarinic; muscarinic acetylcholine; bps associated ... See more keywords
SELECTIVE ACTIONS OF INSECTICIDES ON DESENSITIZING and NON-DESENSITIZING NICOTINIC ACETYLCHOLINE RECEPTORS IN COCKROACH (Periplaneta americana) NEURONS.
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DOI: 10.1002/ps.6396
Abstract: BACKGROUND Insect desensitizing nicotinic acetylcholine (nAChD) receptors are desensitized by low concentrations of agonists, including neonicotinoid insecticides, but are essentially insensitive to spinosyns, while non-desensitizing nicotinic acetylcholine (nAChN) receptors are selectively activated by spinosyns and… read more here.
Keywords: acetylcholine; desensitizing nicotinic; nicotinic acetylcholine; non desensitizing ... See more keywords
Nicotinic α7 acetylcholine receptor (α7nAChR) in human airway smooth muscle.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108897
Abstract: Diseases such as asthma are exacerbated by inflammation, cigarette smoke and even nicotine delivery devices such as e-cigarettes. However, there is currently little information on how nicotine affects airways, particularly in humans, and changes in… read more here.
Keywords: nicotinic acetylcholine; 7nachr human; smooth muscle; acetylcholine receptor ... See more keywords
Nicotinic acetylcholine receptor alpha 7 stimulation dampens splenic myelopoiesis and inhibits atherogenesis in Apoe-/- mice.
Sign Up to like & getrecommendations! Published in 2017 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2017.08.010
Abstract: BACKGROUND AND AIMS Monocyte levels predict cardiovascular outcomes and play a causal role in atherogenesis. Monocytes can be produced in the spleen and track to the atherosclerotic lesion in significant numbers. The cholinergic system has… read more here.
Keywords: splenic myelopoiesis; stimulation; receptor alpha; nicotinic acetylcholine ... See more keywords
Functional characterization of multifunctional ligands targeting acetylcholinesterase and alpha 7 nicotinic acetylcholine receptor.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114010
Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder associated with cholinergic dysfunction, provoking memory loss and cognitive dysfunction in elderly patients. The cholinergic hypothesis provided over the years with molecular targets for developing palliative treatments for… read more here.
Keywords: acetylcholinesterase; nicotinic acetylcholine; receptor; mb105 mb118 ... See more keywords
The p38 mitogen activated protein kinase regulates β-amyloid protein internalization through the α7 nicotinic acetylcholine receptor in mouse brain
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2017.11.006
Abstract: Alzheimer's disease (AD) is one of the most devastating neurodegenerative disorders. Intracellular β-amyloid protein (Aβ) is an early event in AD. It induces the formation of amyloid plaques and neuron damage. The α7 nicotinic acetylcholine… read more here.
Keywords: internalization; acetylcholine receptor; nicotinic acetylcholine; p38 ... See more keywords
Colocalization of association signals at nicotinic acetylcholine receptor genes between schizophrenia and smoking traits.
Sign Up to like & getrecommendations! Published in 2021 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2021.108517
Abstract: BACKGROUND Epidemiological data suggest that smoking may be a risk factor for schizophrenia (SCZ), but more evidence is needed. Two regions coding nicotinic acetylcholine receptor (nAchR) subunits, atCHRNA2 and the CHRNA5/A3/B4 cluster, were associated with… read more here.
Keywords: smoking behaviors; nicotinic acetylcholine; association; scz smoking ... See more keywords
Recurrent autonomic and sensory neuropathy in a patient with anti-ganglionic acetylcholine receptor antibodies
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DOI: 10.1016/j.ensci.2018.08.001
Abstract: We report a case of recurrent neuropathy with predominant autonomic and sensory involvement whose serum was positive for anti-ganglionic acetylcholine receptor (anti-gAChR) antibodies, a diagnostic marker of autoimmune autonomic ganglionopathy. An 11-year-old girl complained of… read more here.
Keywords: acetylcholine receptor; anti; anti ganglionic; autonomic sensory ... See more keywords
Nicotinic acetylcholine receptor alpha 1(nAChRα1) subunit peptides as potential antiviral agents against rabies virus.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.05.179
Abstract: Rabies virus (RABV) is neurotropic and infects all warm-blooded animals. The binding of the virus with host cell receptor components is critical for infection. The present study reports the interaction of nicotinic acetylcholine receptor alpha… read more here.
Keywords: rabies virus; alpha nachr; receptor alpha; nicotinic acetylcholine ... See more keywords