Nicotinic acetylcholine receptors in a songbird brain
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25314
Abstract: Nicotinic acetylcholine receptors (nAChRs) are ligand‐gated ion channels that mediate fast synaptic transmission and cell signaling, which contribute to learning, memory, and the execution of motor skills. Birdsong is a complex learned motor skill in… read more here.
Keywords: acetylcholine receptors; brain; nicotinic acetylcholine; nachr subunits ... See more keywords
Allosteric modulation of α4β2* nicotinic acetylcholine receptors: Desformylflustrabromine potentiates antiallodynic response of nicotine in a mouse model of neuropathic pain
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pain"
DOI: 10.1002/ejp.1092
Abstract: Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand‐gated ion channels. The α4β2 subtype of nAChRs plays an important role in the mediation of pain and several nicotine‐evoked responses. Agonists and partial agonists of α4β2 nAChRs show… read more here.
Keywords: nicotine; acetylcholine receptors; nicotinic acetylcholine; allosteric modulation ... See more keywords
Effects of Chronic Menthol at Alpha3Beta4 (α3β4)-Containing Nicotinic Acetylcholine Receptors
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2017.11.1691
Abstract: Some heteropentameric nicotinic acetylcholine receptors (nAChRs) are up-regulated by chronic nicotine. Menthol is present in ∼ 30% of tobacco cigarettes sold in the United States. Compared with non-mentholated cigarettes, menthol-containing cigarettes are associated with reduced… read more here.
Keywords: acetylcholine receptors; stoichiometry; nicotinic acetylcholine; chronic menthol ... See more keywords
Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.07.082
Abstract: Sleep regulation involves interdependent signaling among specialized neurons in distributed brain regions. Although acetylcholine promotes wakefulness and rapid eye movement (REM) sleep, it is unclear whether the cholinergic pathway is essential (i.e., absolutely required) for… read more here.
Keywords: rem sleep; chrm1 chrm3; sleep; acetylcholine receptors ... See more keywords
Menthol acts as a positive allosteric modulator on nematode levamisole sensitive nicotinic acetylcholine receptors
Sign Up to like & getrecommendations! Published in 2019 at "International Journal for Parasitology: Drugs and Drug Resistance"
DOI: 10.1016/j.ijpddr.2018.12.005
Abstract: The ongoing and widespread emergence of resistance to the existing anti-nematodal pharmacopeia has made it imperative to develop new anthelminthic agents. Historically, plants have been important sources of therapeutic compounds and offer an alternative to… read more here.
Keywords: menthol acts; acetylcholine receptors; levamisole sensitive; nicotinic acetylcholine ... See more keywords
Effects of the antidepressant mirtazapine and zinc on nicotinic acetylcholine receptors
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.12.016
Abstract: Nicotinic acetylcholine receptors (nAChRs) and zinc are associated with regulation of mood and related disorders. In addition, several antidepressants inhibit muscle and neuronal nAChRs and zinc potentiates inhibitory actions of them. Moreover, mirtazapine (a noradrenergic,… read more here.
Keywords: acetylcholine receptors; zinc; nicotinic acetylcholine; mirtazapine ... See more keywords
Molecular characterization and expression profiles of nicotinic acetylcholine receptors in Bradysia odoriphaga.
Sign Up to like & getrecommendations! Published in 2020 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2020.104563
Abstract: Bradysia odoriphaga is a destructive insect pest, damaging more than 30 crop species. Nicotinic acetylcholine receptors (nAChRs) mediating fast excitatory transmission in the central nervous system in insects are the molecular targets of some economically… read more here.
Keywords: nachr subunit; acetylcholine receptors; bradysia odoriphaga; expression profiles ... See more keywords
Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2017.12.005
Abstract: Irreversible inhibition of acetylcholinesterase (AChE) resulting in accumulation of acetylcholine and overstimulation of muscarinic and nicotinic receptors accounts for the acute toxicity of organophosphorus compounds (OP). Accordingly, the mainstay pharmacotherapy against poisoning by OP comprises… read more here.
Keywords: bispyridinium compounds; acetylcholine receptors; acetylcholine; nicotinic acetylcholine ... See more keywords
Discovery, Characterization, and Engineering of LvIC, an α4/4-Conotoxin That Selectively Blocks Rat α6/α3β4 Nicotinic Acetylcholine Receptors.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01786
Abstract: α6β4 nicotinic acetylcholine receptors (nAChRs) are expressed in the central and peripheral nervous systems, but their functions are not fully understood, largely because of a lack of specific ligands. Here, we characterized a novel α-conotoxin,… read more here.
Keywords: discovery characterization; acetylcholine receptors; nicotinic acetylcholine; lvic ... See more keywords
PeIA-5466: A novel peptide antagonist containing non-natural amino acids that selectively targets α3β2 nicotinic acetylcholine receptors.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00566
Abstract: Pharmacologically distinguishing α3β2 nicotinic acetylcholine receptors (nAChRs) from closely related subtypes, particularly α6β2, has been challenging due to the lack of subtype-selective ligands. We created analogs of α-conotoxin (α-Ctx) PeIA to identify ligand-receptor interactions that… read more here.
Keywords: acetylcholine receptors; amino; amino acids; nicotinic acetylcholine ... See more keywords
Development of 11C-Labeled ASEM Analogues for the Detection of Neuronal Nicotinic Acetylcholine Receptors (α7-nAChR)
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.1c00730
Abstract: The homo-pentameric alpha 7 receptor is one of the major types of neuronal nicotinic acetylcholine receptors (α7-nAChRs) related to cognition, memory formation, and attention processing. The mapping of α7-nAChRs by PET pulls a lot of… read more here.
Keywords: acetylcholine receptors; asem analogues; development; nicotinic acetylcholine ... See more keywords