Selected 1,3‐Benzodioxine‐Containing Chalcones as Multipotent Oxidase and Acetylcholinesterase Inhibitors
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DOI: 10.1002/cmdc.202000491
Abstract: Chalcones are considered effective templates for the development of monoamine oxidase (MAO) and cholinesterase (ChE) inhibitors. The present work describes the syntheses of selected 1,3‐benzodioxine‐containing chalcones (CD3, CD8 and CD10), and their inhibitory activities against… read more here.
Keywords: selected benzodioxine; acetylcholinesterase; containing chalcones; benzodioxine containing ... See more keywords
Effects of novel brain‐penetrating oxime acetylcholinesterase reactivators on sarin surrogate‐induced changes in rat brain gene expression
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22755
Abstract: Past assassinations and terrorist attacks demonstrate the need for a more effective antidote against nerve agents and other organophosphates (OP) that cause brain damage through inhibition of acetylcholinesterase (AChE). Our lab has invented a platform… read more here.
Keywords: sarin surrogate; acetylcholinesterase; gene expression; expression ... See more keywords
Piperazine derivatives with potent drug moiety as efficient acetylcholinesterase, butyrylcholinesterase, and glutathione S‐transferase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23259
Abstract: Cholinesterases catalyze the breakdown of the neurotransmitter acetylcholine (ACh), a naturally occurring neurotransmitter, into choline and acetic acid, allowing the nervous system to function properly. In the human body, cholinesterases come in two types, including… read more here.
Keywords: piperazine derivatives; ache bche; bche; butyrylcholinesterase ... See more keywords
Curcumin attenuates memory deficits and the impairment of cholinergic and purinergic signaling in rats chronically exposed to cadmium
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Toxicology"
DOI: 10.1002/tox.22213
Abstract: This study investigated the protective effect of curcumin on memory loss and on the alteration of acetylcholinesterase and ectonucleotidases activities in rats exposed chronically to cadmium (Cd). Rats received Cd (1 mg/kg) and curcumin (30,… read more here.
Keywords: curcumin; acetylcholinesterase; attenuates memory; curcumin curcumin ... See more keywords
Synthesis, computational studies and biological evaluation of new 1-acetyl-3-aryl thiourea derivatives as potent cholinesterase inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-1829-6
Abstract: A new series of 1-acetyl-3-aryl thioureas (3f1–15) was synthesized by the reaction of acetyl isothiocyanate with a variety of suitably substituted aromatic anilines. The acetyl isothiocyanate was freshly prepared by reaction of corresonding acid chloride… read more here.
Keywords: inhibitor; acetyl; acetylcholinesterase; acetyl aryl ... See more keywords
Green Roccella phycopsis Ach. mediated silver nanoparticles: synthesis, characterization, phenolic content, antioxidant, antibacterial and anti-acetylcholinesterase capacities
Sign Up to like & getrecommendations! Published in 2021 at "Bioprocess and Biosystems Engineering"
DOI: 10.1007/s00449-021-02601-y
Abstract: In this study, we develop here for the first time an easy, eco-friendly method for synthesizing silver nanoparticles (AgNPs) using the lichen Roccella phycopsis. AgNPs formation was first determined by a color change of the… read more here.
Keywords: silver nanoparticles; acetylcholinesterase; roccella phycopsis; spectroscopy ... See more keywords
Potential acetylcholinesterase inhibitors: molecular docking, molecular dynamics, and in silico prediction
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DOI: 10.1007/s00894-017-3228-9
Abstract: AbstractThis paper deals with molecular modeling of new therapeutic agents for treating the Alzheimer’s disease. The therapeutic line adopted for this study is the cholinergic hypothesis. To modulate positively the cholinergic function through the inhibition… read more here.
Keywords: acetylcholinesterase; docking molecular; acetylcholinesterase inhibitors; inhibitors molecular ... See more keywords
Effect of Thiazolidin-4-one Against Lipopolysaccharide-Induced Oxidative Damage, and Alterations in Adenine Nucleotide Hydrolysis and Acetylcholinesterase Activity in Cultured Astrocytes.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-021-01177-1
Abstract: Astrocytes play multiple important roles in brain physiology. However, depending on the stimuli, astrocytes may exacerbate inflammatory reactions, contributing to the development and progression of neurological diseases. Therefore, therapies targeting astrocytes represent a promising area… read more here.
Keywords: damage; acetylcholinesterase; effect; activity ... See more keywords
Chagas disease: modulation of the inflammatory response by acetylcholinesterase in hematological cells and brain tissue
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-3113-y
Abstract: Chagas disease is an acute or chronic illness that causes severe inflammatory response, and consequently, it may activate the inflammatory cholinergic pathway, which is regulated by cholinesterases, including the acetylcholinesterase. This enzyme is responsible for… read more here.
Keywords: acetylcholinesterase; response; inflammatory response; brain ... See more keywords
Effect of pregnancy on the cholinergic responses of the bladder: role of acetylcholinesterase
Sign Up to like & getrecommendations! Published in 2018 at "International Urology and Nephrology"
DOI: 10.1007/s11255-018-2032-5
Abstract: ObjectivesPregnancy is associated with many functional changes of the urinary bladder. It was reported that most of healthy women complain from urinary symptoms during pregnancy. The parasympathetic system is mainly mediating bladder emptying. The aim… read more here.
Keywords: pregnancy; acetylcholinesterase; control; bladder ... See more keywords
Stilbenoids isolated from the roots of Rheum lhasaense under the guidance of the acetylcholinesterase inhibition activity.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of natural medicines"
DOI: 10.1007/s11418-020-01478-7
Abstract: Four unknown stilbenoids, including one dimer, namely 4'-methoxy-scirpusin A (5) and three monomeric stilbene glycosides, namely piceatannol-3'-O-[2''-(3,5-dihydroxy-4-methoxybenzoyl)]-β-D-glucopyranoside (13), piceatannol-3'-O-(2''-galloyl)-β-D-glucopyranoside (14) and piceatannol-3'-O-(6″-p-coumaroyl)-β-D-glucopyranoside (16) together with 15 described compounds, were isolated from the ethyl acetate fraction… read more here.
Keywords: acetylcholinesterase; stilbenoids isolated; roots rheum; guidance ... See more keywords