Increased acetylcholinesterase inhibitor sensitivity as an intergenerational response to short-term acetylcholinesterase inhibitor exposure in Scapholeberis kingi
Sign Up to like & getrecommendations! Published in 2019 at "Limnology"
DOI: 10.1007/s10201-019-00598-8
Abstract: To determine the potential long-term risks associated with continual use of pesticides, we investigated (1) whether short-term exposure (48 h) of first generation (1G) Scapholeberis kingi to two acetylcholinesterase-inhibitor insecticides, pyraclofos and pirimicarb, would alter… read more here.
Keywords: inhibitor; term; acetylcholinesterase inhibitor; exposure ... See more keywords
Acetylcholinesterase Inhibitors in Myasthenic Crisis: A Systematic Review of Observational Studies
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DOI: 10.1007/s12028-021-01259-4
Abstract: Current myasthenia gravis guidelines recommend intravenous immunoglobulin or plasmapheresis and discontinuation of pyridostigmine during myasthenic crisis. However, intravenous immunoglobulin or plasmapheresis is expensive and frequently not available in developing countries. This study aims to summarize… read more here.
Keywords: acetylcholinesterase inhibitor; observational studies; myasthenic crisis; crisis ... See more keywords
Acetylcholinesterase inhibitor ameliorates doxorubicin-induced cardiotoxicity through reducing RIP1-mediated necroptosis.
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DOI: 10.1016/j.phrs.2021.105882
Abstract: Doxorubicin is an effective chemotherapeutic drug, but causes cardiotoxicity which limits its use. Oxidative stress, mitochondrial dysfunction, and inflammation are closely implicated in doxorubicin-induced cardiotoxicity (DIC). Necroptosis, a new form of programmed cell death, was… read more here.
Keywords: induced cardiotoxicity; doxorubicin induced; acetylcholinesterase inhibitor; dysfunction ... See more keywords
White matter hyperintensities in cholinergic pathways may predict poorer responsiveness to acetylcholinesterase inhibitor treatment for Alzheimer’s disease
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DOI: 10.1371/journal.pone.0283790
Abstract: Background Acetylcholinesterase inhibitor (AChEI) drug regimens are the mainstay treatment options for patients with Alzheimer’s disease (AD). Herein, We examined the association between clinical response to AChEI and white matter hyperintensities on magnetic resonance imaging… read more here.
Keywords: white matter; alzheimer disease; acetylcholinesterase inhibitor; cholinergic pathways ... See more keywords
Structure-Based Design and Molecular Dynamics Simulations of Pentapeptide AEYTR as a Potential Acetylcholinesterase Inhibitor
Sign Up to like & getrecommendations! Published in 2020 at "Indonesian Journal of Chemistry"
DOI: 10.22146/ijc.46329
Abstract: Structure-based virtual screening protocol to identify potent acetylcholinesterase inhibitors was retrospectively validated. The protocol could be employed to examine the potential of designed compounds as novel acetylcholinesterase inhibitors. In a research project designing short peptides… read more here.
Keywords: dynamics simulations; molecular dynamics; structure based; acetylcholinesterase ... See more keywords