Acetylcholinesterase Inhibitors Are Associated with Reduced Fracture Risk among Older Veterans with Dementia
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3916
Abstract: Acetylcholinesterase inhibitors (AChEIs) have been noted to increase bone density and quality in mice. Human studies are limited but suggest an association with improved bone healing after hip fracture. We examined the relationship between AChEI… read more here.
Keywords: older veterans; risk; fracture; acetylcholinesterase inhibitors ... See more keywords
An efficient strategy based on two-stage chromatography and in vitro evaluation for rapid screening and isolation of acetylcholinesterase inhibitors from Scutellaria baicalensis Georgi.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202100918
Abstract: The extraction of Scutellaria baicalensis Georgi was investigated using the response surface methodology-genetic algorithm mathematical regression model, and the extraction variables were optimized to maximize the flavonoid yield. Furthermore, a simple and efficient ultrafiltration-liquid chromatography-mass… read more here.
Keywords: acetylcholinesterase inhibitors; chromatography; scutellaria baicalensis; baicalensis georgi ... See more keywords
Potential acetylcholinesterase inhibitors: molecular docking, molecular dynamics, and in silico prediction
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-017-3228-9
Abstract: AbstractThis paper deals with molecular modeling of new therapeutic agents for treating the Alzheimer’s disease. The therapeutic line adopted for this study is the cholinergic hypothesis. To modulate positively the cholinergic function through the inhibition… read more here.
Keywords: acetylcholinesterase; docking molecular; acetylcholinesterase inhibitors; inhibitors molecular ... See more keywords
2D-SAR and 3D-QSAR analyses for acetylcholinesterase inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Diversity"
DOI: 10.1007/s11030-017-9732-0
Abstract: Alzheimer’s disease (AD) accounts for almost three quarters of dementia patients and interferes people’s normal life. Great progress has been made recently in the study of Acetylcholinesterase (AChE), known as one of AD’s biomarkers. In… read more here.
Keywords: acetylcholinesterase inhibitors; qsar analyses; sar qsar; model ... See more keywords
Novel nicotinonitrile-coumarin hybrids as potential acetylcholinesterase inhibitors: design, synthesis, in vitro and in silico studies
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-020-02018-6
Abstract: Abstract Alzheimer’s disease is a degenerative brain condition that is the leading cause of dementia affecting millions of people around the world. Therapeutic development has focused on the problem of the loss of basal forebrain… read more here.
Keywords: nicotinonitrile coumarin; hybrids potential; acetylcholinesterase inhibitors; coumarin hybrids ... See more keywords
Synthesis and molecular dynamic simulation studies of novel N-(1-benzylpiperidin-4-yl) quinoline-4-carboxamides as potential acetylcholinesterase inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.130919
Abstract: Abstract A new series of N-(1-benzylpiperidin-4-yl) quinoline-4-carboxamide derivatives was designed and synthesized as potential acetylcholinesterase inhibitors. The compounds were characterized by nuclear magnetic resonance, infrared and mass spectrometry. In the amidation reaction in addition of… read more here.
Keywords: potential acetylcholinesterase; acetylcholinesterase inhibitors; benzylpiperidin quinoline; synthesis molecular ... See more keywords
Novel series of triazole containing coumarin and isatin based hybrid molecules as acetylcholinesterase inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131085
Abstract: Abstract Novel series of coumarin-triazole and isatin-triazole hybrids were rationally designed, synthesized and biologically evaluated to check their inhibitory potential against acetylcholinesterase enzyme by using in vitro Ellman's method. Most of the hybrid compounds showed… read more here.
Keywords: acetylcholinesterase inhibitors; novel series; coumarin; series triazole ... See more keywords
The effects of acetylcholinesterase inhibitors on morbidity after general anesthesia and surgery
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108134
Abstract: Non-depolarizing neuromuscular blocking agents are used during general anesthesia to facilitate intubation and optimize surgical conditions. When patients leave the operating room after surgery, postoperative residual neuromuscular block occurs frequently, increasing vulnerability to respiratory complications… read more here.
Keywords: surgery; acetylcholinesterase inhibitors; effects acetylcholinesterase; inhibitors morbidity ... See more keywords
Combined Structure and Ligand-Based Design of Selective Acetylcholinesterase Inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.0c00463
Abstract: Acetylcholinesterase is a prime target for therapeutic intervention in Alzheimer's disease. Acetylcholinesterase inhibitors (AChEIs) are used to improve cognitive abilities, playing therefore an important role in disease management. Drug repurposing screening has been performed on… read more here.
Keywords: acetylcholinesterase; combined structure; acetylcholinesterase inhibitors; drug ... See more keywords
Facile and visual detection of acetylcholinesterase inhibitors by carbon quantum dots
Sign Up to like & getrecommendations! Published in 2019 at "New Journal of Chemistry"
DOI: 10.1039/c9nj02347j
Abstract: Sensitive and rapid detection of organophosphate toxicants is highly relevant and important in environmental protection and food safety. read more here.
Keywords: acetylcholinesterase inhibitors; visual detection; detection acetylcholinesterase; inhibitors carbon ... See more keywords
Acetylcholinesterase inhibitors to enhance recovery from traumatic brain injury: a comprehensive review and case series
Sign Up to like & getrecommendations! Published in 2022 at "Brain Injury"
DOI: 10.1080/02699052.2022.2034962
Abstract: ABSTRACT Objective Acetylcholinesterase inhibitors (AChEIs) are used off-label, in both adult and pediatric patients, to help further neuro-recovery after traumatic brain injury (TBI). Evidence is limited and piecemeal. This review describes how TBI affects the… read more here.
Keywords: injury; acetylcholinesterase inhibitors; recovery traumatic; brain injury ... See more keywords