N‐acetylcysteine targets 5 lipoxygenase‐derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice
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DOI: 10.1002/ana.25356
Abstract: N‐acetylcysteine (NAC) is a clinically approved thiol‐containing redox modulatory compound currently in trials for many neurological and psychiatric disorders. Although generically labeled as an “antioxidant,” poor understanding of its site(s) of action is a barrier… read more here.
Keywords: hemorrhagic stroke; acetylcysteine targets; lipoxygenase derived; toxic lipids ... See more keywords