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   Articles with "acetyltransferase" as a keyword



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EpsM from Bacillus subtilis 168 has UDP-2,4,6-trideoxy-2-acetamido-4-amino glucose acetyltransferase activity in vitro.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.09.185

Abstract: Bacillus subtilis 168 EpsM (UniProt id P71063) has been electronically annotated as putative acetyltransferase in the UniProt database. The gene epsM was cloned and overexpressed in E. coli with an N-terminal GST tag. The purified fusion… read more here.

Keywords: trideoxy acetamido; acetamido amino; acetyltransferase; subtilis 168 ... See more keywords
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Expression and genotype‐dependent catalytic activity of N‐acetyltransferase 2 (NAT2) in human peripheral blood mononuclear cells and its modulation by Sirtuin 1

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recommendations! Published in 2018 at "Biochemical Pharmacology"

DOI: 10.1016/j.bcp.2018.08.034

Abstract: Graphical abstract Figure. No Caption available. Abstract N‐acetyltransferase 2 (NAT2) catalyzes the biotransformation of numerous arylamine and hydrazine drugs and carcinogens. Genetic polymorphisms of NAT2 modify drug efficacy and toxicity and susceptibility to diseases such… read more here.

Keywords: sirt1; blood mononuclear; acetyltransferase; peripheral blood ... See more keywords
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Allosteric regulation of arylamine N‐acetyltransferase 1 by adenosine triphosphate

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recommendations! Published in 2018 at "Biochemical Pharmacology"

DOI: 10.1016/j.bcp.2018.10.013

Abstract: &NA; In the present study, a screen of adenosine analogs as potential modulators of arylamine‐N‐acetyltransferase 1 activity identified ATP as an inhibitor within its range of physiological concentrations. Kinetically, ATP was a non‐competitive inhibitor with… read more here.

Keywords: allosteric regulation; acetyltransferase; lysine 100; triphosphate ... See more keywords
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NuA4 acetyltransferase is required for efficient nucleotide excision repair in yeast.

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recommendations! Published in 2019 at "DNA repair"

DOI: 10.1016/j.dnarep.2018.11.006

Abstract: The nucleotide excision repair (NER) pathway is critical for removing damage induced by ultraviolet (UV) light and other helix-distorting lesions from cellular DNA. While efficient NER is critical to avoid cell death and mutagenesis, NER… read more here.

Keywords: nucleotide excision; acetyltransferase; required efficient; excision repair ... See more keywords
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Chemoproteomic Profiling of Protein Substrates of a Major Lysine Acetyltransferase in the Native Cellular Context.

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recommendations! Published in 2022 at "ACS chemical biology"

DOI: 10.1021/acschembio.1c00935

Abstract: The family of lysine acetyltransferases (KATs) regulates epigenetics and signaling pathways in eukaryotic cells. So far, knowledge of different KAT members contributing to the cellular acetylome is limited, which limits our understanding of biological functions… read more here.

Keywords: coa; acetyltransferase; protein substrates; profiling ... See more keywords

Histone N-terminal acetyltransferase NAA40 links one-carbon metabolism to chemoresistance

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recommendations! Published in 2021 at "Oncogene"

DOI: 10.1038/s41388-021-02113-9

Abstract: Aberrant function of epigenetic modifiers plays an important role not only in the progression of cancer but also the development of drug resistance. N-alpha-acetyltransferase 40 (NAA40) is a highly specific epigenetic enzyme catalyzing the transfer… read more here.

Keywords: acetyltransferase naa40; chemoresistance; acetyltransferase; cancer ... See more keywords
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The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-08579-2

Abstract: The Elongator complex catalyzes posttranscriptional tRNA modifications by attaching carboxy-methyl (cm5) moieties to uridine bases located in the wobble position. The catalytic subunit Elp3 is highly conserved and harbors two individual subdomains, a radical S-adenosyl… read more here.

Keywords: elp3; acetyltransferase; elongator; subunit elp3 ... See more keywords
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Transcription factor dimerization activates the p300 acetyltransferase

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recommendations! Published in 2018 at "Nature"

DOI: 10.1038/s41586-018-0621-1

Abstract: The transcriptional co-activator p300 is a histone acetyltransferase (HAT) that is typically recruited to transcriptional enhancers and regulates gene expression by acetylating chromatin. Here we show that the activation of p300 directly depends on the… read more here.

Keywords: transcription; acetyltransferase; transcription factor; activation ... See more keywords

Acetylation in the regulation of autophagy

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recommendations! Published in 2022 at "Autophagy"

DOI: 10.1080/15548627.2022.2062112

Abstract: ABSTRACT Post-translational modifications, such as phosphorylation, ubiquitination and acetylation, play crucial roles in the regulation of autophagy. Acetylation has emerged as an important regulatory mechanism for autophagy. Acetylation regulates autophagy initiation and autophagosome formation by… read more here.

Keywords: acetyltransferase; acetylation; kinase; autophagy acetylation ... See more keywords
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NAA50 Is an Enzymatically Active Nα-Acetyltransferase That Is Crucial for Development and Regulation of Stress Responses1[OPEN]

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recommendations! Published in 2020 at "Plant Physiology"

DOI: 10.1104/pp.20.00222

Abstract: Knockout of an N-acetyltransferase, AtNAA50, causes arrest of growth in the model plant Arabidopsis but does not affect the activity of the essential NatA complex. Nα-terminal acetylation (NTA) is a prevalent protein modification in eukaryotes.… read more here.

Keywords: arabidopsis; acetyltransferase; nata; naa50 ... See more keywords

HYPK promotes the activity of the Nα-acetyltransferase A complex to determine proteostasis of nonAc-X2/N-degron–containing proteins

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recommendations! Published in 2022 at "Science Advances"

DOI: 10.1126/sciadv.abn6153

Abstract: In humans, the Huntingtin yeast partner K (HYPK) binds to the ribosome-associated Nα-acetyltransferase A (NatA) complex that acetylates ~40% of the proteome in humans and Arabidopsis thaliana. However, the relevance of HsHYPK for determining the… read more here.

Keywords: acetyltransferase; nonac degron; degron; activity ... See more keywords