NAA10 p.(N101K) disrupts N-terminal acetyltransferase complex NatA and is associated with developmental delay and hemihypertrophy
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Human Genetics"
DOI: 10.1038/s41431-020-00728-2
Abstract: Nearly half of all human proteins are acetylated at their N-termini by the NatA N-terminal acetyltransferase complex. NAA10 is evolutionarily conserved as the catalytic subunit of NatA in complex with NAA15, but may also have… read more here.
Keywords: developmental delay; acetyltransferase complex; terminal acetyltransferase; naa10 n101k ... See more keywords
Mechanistic insights into histone recognition and H3K14 acetylation by the NuA3 histone acetyltransferase complex.
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DOI: 10.1038/s41467-025-67049-0
Abstract: The NuA3 histone acetyltransferase complex in budding yeast, composed of six subunits, specifically acetylates lysine 14 on histone H3 (H3K14), thereby regulating various biological processes. Despite its importance, the structural basis and mechanism underlying histone… read more here.
Keywords: nua3 histone; histone acetyltransferase; h3k14; acetyltransferase complex ... See more keywords
Structure of the NuA4 histone acetyltransferase complex
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214313119
Abstract: Significance The structure of NuA4, one of two major histone acetyltransferases of Saccharomyces cerevisiae, is reported at 3.8 Å resolution. Six polypeptide chains of the complex, comprising about half the total mass, could be traced.… read more here.
Keywords: structure; histone acetyltransferase; nua4 histone; acetyltransferase complex ... See more keywords
The MOZ-BRPF1 acetyltransferase complex in epigenetic crosstalk linked to gene regulation, development, and human diseases
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1115903
Abstract: Acetylation of lysine residues on histone tails is an important post-translational modification (PTM) that regulates chromatin dynamics to allow gene transcription as well as DNA replication and repair. Histone acetyltransferases (HATs) are often found in… read more here.
Keywords: acetyltransferase; epigenetic crosstalk; acetyltransferase complex; moz brpf1 ... See more keywords
The Verticillium dahliae Spt-Ada-Gcn5 Acetyltransferase Complex Subunit Ada1 Is Essential for Conidia and Microsclerotia Production and Contributes to Virulence
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.852571
Abstract: Verticillium dahliae is a destructive soil-borne pathogen of many economically important dicots. The genetics of pathogenesis in V. dahliae has been extensively studied. Spt-Ada-Gcn5 acetyltransferase complex (SAGA) is an ATP-independent multifunctional chromatin remodeling complex that… read more here.
Keywords: dahliae; gcn5 acetyltransferase; verticillium dahliae; spt ada ... See more keywords