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Published in 2018 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201700273
Abstract: A series of N‐substituted‐5‐chloro‐2(3H)‐benzoxazolone derivatives were synthesized and evaluated for their acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) inhibitory, and antioxidant activities. The structures of the title compounds were confirmed by spectral and elemental analyses. The cholinesterase (ChE)…
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Keywords:
ache;
chloro benzoxazolone;
compound;
synthesis biological ... See more keywords
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Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200142
Abstract: Alzheimer's disease (AD) is a degenerative neurological disease characterized by gradual loss of cognitive skills and memory. The exact pathogenesis involved still remains unrevealed, but several studies indicate the involvement of an array of different…
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Keywords:
inhibition;
toward cholinesterase;
taddol derivatives;
cholinesterase inhibition ... See more keywords
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Published in 2021 at "ChemMedChem"
DOI: 10.1002/cmdc.202100272
Abstract: Novel pyridine‐containing sultones were synthesized and evaluated for their cholinesterase (ChE) inhibitory activity. Most of compounds showed selective acetylcholinesterase (AChE) inhibitory activity. The structure‐activity relationship (SAR) showed: (i) the fused pyridine‐containing sultones increase AChE inhibition,…
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Keywords:
ache;
novel pyridine;
containing sultones;
pyridine containing ... See more keywords
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Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21998
Abstract: Natural products have significantly contributed to drug discovery for neurodegenerative diseases. Caffeine is one of the well‐known central nervous system(CNS)‐active natural products. Besides its CNS stimulant properties, it is a mild inhibitor of acetylcholinesterase (AChE)…
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Keywords:
bace;
caffeine based;
caffeine;
ache ... See more keywords
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Published in 2018 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.201700130
Abstract: In this study, polyacrylic acid‐based nanofiber (NF) membrane was prepared via electrospinning method. Acetylcholinesterase (AChE) from Electrophorus electricus was covalently immobilized onto polyacrylic acid‐based NF membrane by demonstrating efficient enzyme immobilization, and immobilization capacity of…
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Keywords:
ache;
acid based;
immobilization;
polyacrylic acid ... See more keywords
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Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30277
Abstract: Alzheimer's disease (AD) is the leading cause of dementia worldwide. Despite causing great social and economic impact, there is currently no cure for AD. The most effective therapy to manage AD symptoms is based on…
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Keywords:
analyses acetylcholinesterase;
interaction;
ache;
silico analyses ... See more keywords
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Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200047
Abstract: A novel acetylcholinesterase (AChE) Nano LC capillary column (75μm i.d * 50 mm length) was developed for the fast screening of AChE inhibitors and the evaluation of their molecular recognition mechanism. Biotinylated AChE was immobilized…
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Keywords:
nano capillary;
capillary column;
ache;
development nano ... See more keywords
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Published in 2019 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-019-02488-1
Abstract: In our search for novel bioactive molecules, three series of indolin-2-one derivatives incorporating 1-benzyl-1H-1,2,3-triazole moiety were synthesized. The compounds were initially designed as acetylcholine esterase (AChE) inhibitors based on the structural feature of donepezil, a…
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Keywords:
benzyl triazole;
ache;
incorporating benzyl;
one derivatives ... See more keywords
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Published in 2019 at "Aquaculture International"
DOI: 10.1007/s10499-019-00497-w
Abstract: In Brazilian fish farms, trichlorfon has been widely used to control acanthocephalan infections in Colossoma macropomum. Toxicity tests were conducted to estimate the median lethal concentration (LC50–96 h) and evaluate the effects of trichlorfon on…
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Keywords:
ache;
trichlorfon;
muscle;
toxicity ... See more keywords
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Published in 2019 at "Inflammation"
DOI: 10.1007/s10753-019-01018-w
Abstract: Species from Psychotria are used in folk medicine against inflammatory diseases, respiratory disturbances, and anti-hallucinogenic. In the present study, the compound vincosamide (PL-1) was identified for the first time in methanolic extract of the Psychotria…
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Keywords:
ache;
activity;
mice;
psychotria leiocarpa ... See more keywords
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Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-3246-z
Abstract: This work focused on finding a relationship between acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities and the development and severity of COPD. The possible link of these enzymes to oxidative and inflammatory processes was also investigated.…
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Keywords:
ache;
butyrylcholinesterase;
bche activities;
bche ... See more keywords