Articles with "ache" as a keyword



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Synthesis, biological evaluation, and docking studies of some 5‐chloro‐2(3H)‐benzoxazolone Mannich bases derivatives as cholinesterase inhibitors

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Published in 2018 at "Archiv der Pharmazie"

DOI: 10.1002/ardp.201700273

Abstract: A series of N‐substituted‐5‐chloro‐2(3H)‐benzoxazolone derivatives were synthesized and evaluated for their acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) inhibitory, and antioxidant activities. The structures of the title compounds were confirmed by spectral and elemental analyses. The cholinesterase (ChE)… read more here.

Keywords: ache; chloro benzoxazolone; compound; synthesis biological ... See more keywords
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Toward the cholinesterase inhibition potential of TADDOL derivatives: Seminal biological and computational studies

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Published in 2022 at "Archiv der Pharmazie"

DOI: 10.1002/ardp.202200142

Abstract: Alzheimer's disease (AD) is a degenerative neurological disease characterized by gradual loss of cognitive skills and memory. The exact pathogenesis involved still remains unrevealed, but several studies indicate the involvement of an array of different… read more here.

Keywords: inhibition; toward cholinesterase; taddol derivatives; cholinesterase inhibition ... See more keywords
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Novel Pyridine‐Containing Sultones: Structure‐Activity Relationship and Biological Evaluation as Selective AChE Inhibitors for the Treatment of Alzheimer's disease

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Published in 2021 at "ChemMedChem"

DOI: 10.1002/cmdc.202100272

Abstract: Novel pyridine‐containing sultones were synthesized and evaluated for their cholinesterase (ChE) inhibitory activity. Most of compounds showed selective acetylcholinesterase (AChE) inhibitory activity. The structure‐activity relationship (SAR) showed: (i) the fused pyridine‐containing sultones increase AChE inhibition,… read more here.

Keywords: ache; novel pyridine; containing sultones; pyridine containing ... See more keywords
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Design, synthesis, and structure–activity relationship of caffeine‐based triazoles as dual AChE and BACE‐1 inhibitors

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Published in 2022 at "Drug Development Research"

DOI: 10.1002/ddr.21998

Abstract: Natural products have significantly contributed to drug discovery for neurodegenerative diseases. Caffeine is one of the well‐known central nervous system(CNS)‐active natural products. Besides its CNS stimulant properties, it is a mild inhibitor of acetylcholinesterase (AChE)… read more here.

Keywords: bace; caffeine based; caffeine; ache ... See more keywords
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Covalent immobilization of acetylcholinesterase on a novel polyacrylic acid‐based nanofiber membrane

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Published in 2018 at "Engineering in Life Sciences"

DOI: 10.1002/elsc.201700130

Abstract: In this study, polyacrylic acid‐based nanofiber (NF) membrane was prepared via electrospinning method. Acetylcholinesterase (AChE) from Electrophorus electricus was covalently immobilized onto polyacrylic acid‐based NF membrane by demonstrating efficient enzyme immobilization, and immobilization capacity of… read more here.

Keywords: ache; acid based; immobilization; polyacrylic acid ... See more keywords
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In silico analyses of acetylcholinesterase (AChE) and its genetic variants in interaction with the anti‐Alzheimer drug Rivastigmine

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Published in 2022 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.30277

Abstract: Alzheimer's disease (AD) is the leading cause of dementia worldwide. Despite causing great social and economic impact, there is currently no cure for AD. The most effective therapy to manage AD symptoms is based on… read more here.

Keywords: analyses acetylcholinesterase; interaction; ache; silico analyses ... See more keywords
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Development of nano Bio LC columns for the search of acethylcholinesterase molecular targets.

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Published in 2022 at "Journal of separation science"

DOI: 10.1002/jssc.202200047

Abstract: A novel acetylcholinesterase (AChE) Nano LC capillary column (75μm i.d * 50 mm length) was developed for the fast screening of AChE inhibitors and the evaluation of their molecular recognition mechanism. Biotinylated AChE was immobilized… read more here.

Keywords: nano capillary; capillary column; ache; development nano ... See more keywords
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Design, synthesis, and bioevaluation of novel oxoindolin-2-one derivatives incorporating 1-benzyl-1H-1,2,3-triazole

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Published in 2019 at "Medicinal Chemistry Research"

DOI: 10.1007/s00044-019-02488-1

Abstract: In our search for novel bioactive molecules, three series of indolin-2-one derivatives incorporating 1-benzyl-1H-1,2,3-triazole moiety were synthesized. The compounds were initially designed as acetylcholine esterase (AChE) inhibitors based on the structural feature of donepezil, a… read more here.

Keywords: benzyl triazole; ache; incorporating benzyl; one derivatives ... See more keywords
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Acute toxicity of the pesticide trichlorfon and inhibition of acetylcholinesterase in Colossoma macropomum (Characiformes: Serrasalmidae)

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Published in 2019 at "Aquaculture International"

DOI: 10.1007/s10499-019-00497-w

Abstract: In Brazilian fish farms, trichlorfon has been widely used to control acanthocephalan infections in Colossoma macropomum. Toxicity tests were conducted to estimate the median lethal concentration (LC50–96 h) and evaluate the effects of trichlorfon on… read more here.

Keywords: ache; trichlorfon; muscle; toxicity ... See more keywords
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Psychotria leiocarpa Extract and Vincosamide Reduce Chemically-Induced Inflammation in Mice and Inhibit the Acetylcholinesterase Activity

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Published in 2019 at "Inflammation"

DOI: 10.1007/s10753-019-01018-w

Abstract: Species from Psychotria are used in folk medicine against inflammatory diseases, respiratory disturbances, and anti-hallucinogenic. In the present study, the compound vincosamide (PL-1) was identified for the first time in methanolic extract of the Psychotria… read more here.

Keywords: ache; activity; mice; psychotria leiocarpa ... See more keywords
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Alterations in acetylcholinesterase and butyrylcholinesterase activities in chronic obstructive pulmonary disease: relationships with oxidative and inflammatory markers

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Published in 2017 at "Molecular and Cellular Biochemistry"

DOI: 10.1007/s11010-017-3246-z

Abstract: This work focused on finding a relationship between acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities and the development and severity of COPD. The possible link of these enzymes to oxidative and inflammatory processes was also investigated.… read more here.

Keywords: ache; butyrylcholinesterase; bche activities; bche ... See more keywords