On-substrate Enzymatic Reaction to Determine Acetylcholinesterase Activity in Whole Blood by Paper Spray Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Society for Mass Spectrometry"
DOI: 10.1007/s13361-018-2072-1
Abstract: AbstractCurrently, all assays measuring acetylcholinesterase (AChE) activity following a suspected nerve agent exposure leverage methodologies that fail to identify the agent. This limits the overall effectiveness and ability to administer proper countermeasures. As such, there is an… read more here.
Keywords: ache activity; paper spray; paper; activity ... See more keywords
Concurrent urinary organophosphate metabolites and acetylcholinesterase activity in Ecuadorian adolescents.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental research"
DOI: 10.1016/j.envres.2021.112163
Abstract: BACKGROUND Organophosphates are insecticides that inhibit the enzymatic activity of acetylcholinesterase (AChE). Because of this, AChE is considered a physiological marker of organophosphate exposure in agricultural settings. However, limited research exists on the associations between… read more here.
Keywords: ache; july october; ache activity; urinary organophosphate ... See more keywords
Study of acetylcholinesterase activity and apoptosis in SH-SY5Y cells and mice exposed to ethanol.
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology"
DOI: 10.1016/j.tox.2017.04.007
Abstract: Ethanol is one of the most commonly abused psychotropic substances with deleterious effects on the central nervous system. Ethanol exposure during development results in the loss of neurons in brain regions and when exposed to… read more here.
Keywords: ache activity; exposed ethanol; activity; apoptosis ... See more keywords
Inhibition of cholinesterases following percutaneous intoxication with V agents in rats
Sign Up to like & getrecommendations! Published in 2019 at "Toxin Reviews"
DOI: 10.1080/15569543.2018.1564773
Abstract: Abstract Female Wistar rats were percutaneously (p.c.) intoxicated (1xLD50) with VX and its two derivatives differing in their substitution on nitrogen (diethyl- and dibutyl- derivatives). Blood cholinesterase activity was continuously monitored; 100 min after the intoxication… read more here.
Keywords: ache activity; intoxication; activity; inhibition cholinesterases ... See more keywords
Pro: Oximes should be used routinely in organophosphate poisoning
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.15215
Abstract: In poisoning with organophosphorus compounds (OP), patients can only profit from the regeneration of acetylcholinesterase, when the poison load has dropped below a toxic level. Every measure that allows an increase of synaptic acetylcholinesterase (AChE)… read more here.
Keywords: ache activity; reactivation; ache; activity ... See more keywords
Development of an in vitro potency assay for human skeletal muscle derived cells
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0194561
Abstract: Background Potency is a quantitative measure of the desired biological function of an advanced therapy medicinal product (ATMP) and is a prerequisite for market approval application (MAA). To assess the potency of human skeletal muscle-derived… read more here.
Keywords: ache activity; skeletal muscle; potency;
Sepsis decreases the activity of acetylcholinesterase by reducing its expression at the neuromuscular junction.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.7265
Abstract: Our previous study demonstrated that sepsis may decrease the activity of acetylcholinesterase (AChE) at the neuromuscular junction (NMJ) of the diaphragm at 24 h, and thus improve the antagonistic action of neostigmine on rocuronium. The present… read more here.
Keywords: sepsis; activity acetylcholinesterase; expression; ache activity ... See more keywords