New hybrids of tacrine and indomethacin as multifunctional acetylcholinesterase inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Papers"
DOI: 10.1007/s11696-020-01295-y
Abstract: A new series of hybrid compounds were designed, consisting of anti-AChE and BuChE activity components with an anti-inflammatory component. A series of 9-amino-1,2,3,4-tetrahydroacridine and indomethacin derivatives were synthesized. All compounds were created using alkyldiamine with… read more here.
Keywords: acetylcholinesterase; activity; new hybrids; ache buche ... See more keywords
Structural analysis of halogenated bicyclo[4.2.0] inositols, biological activities and molecular docking studies
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131357
Abstract: Abstract The halogenated bicyclo[4.2.0] inositols (chiro-, scyllo- and muco-inositol derivatives) and a cyclic sulfate were obtained using cyclooctatetraene (COT). One of these structures (tetrol 12) was resolved by X-ray diffraction and the stereochemistry of the… read more here.
Keywords: halogenated bicyclo; docking studies; ache buche; bicyclo inositols ... See more keywords
Discovery of New 1,3,4-Oxadiazoles with Dual Activity Targeting the Cholinergic Pathway as Effective Anti-Alzheimer Agents.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00766
Abstract: Finding an effective anti-Alzheimer agent is quite challenging due to its multifactorial nature. As such, multitarget directed ligands (MTDLs) could be a promising paradigm for finding potential therapeutically effective new small-molecule bioactive agents against Alzheimer's… read more here.
Keywords: ache buche; buche; anti alzheimer; effective anti ... See more keywords
Aaptamine – a dual acetyl – and butyrylcholinesterase inhibitor as potential anti-Alzheimer’s disease agent
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2102657
Abstract: Abstract Context Alzheimer’s disease (AD) is a neurodegenerative disorder that affects millions of people worldwide. Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) are promising therapeutic targets for AD. Objective To evaluate the inhibitory effects of aaptamine on… read more here.
Keywords: alzheimer disease; buche; anti; ache buche ... See more keywords