Self‐Assembly of Copper Polypyridyl Supramolecular Metallopolymers to Achieve Enhanced Anticancer Efficacy
Sign Up to like & getrecommendations! Published in 2019 at "ChemistryOpen"
DOI: 10.1002/open.201900036
Abstract: Abstract Self‐assembled functional supramolecular metallopolymers have demonstrated application potential in cancer therapy. Herein, a copper polypyridyl complex was found able to self‐assemble into a supramolecular metallopolymer driven by the intermolecular interactions, which could enhance the… read more here.
Keywords: achieve enhanced; supramolecular metallopolymers; copper polypyridyl; anticancer efficacy ... See more keywords
Rationally Designed Amanitins Achieve Enhanced Cytotoxicity.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02226
Abstract: For 70 years, α-amanitin, the most cytotoxic peptide in its class, has been without a synthetic rival; through synthesis, we address the structure-activity relationships to inform the design of new amatoxins and disclose analogues that… read more here.
Keywords: rationally designed; cytotoxicity; designed amanitins; enhanced cytotoxicity ... See more keywords