Chemical labeling achieves 8-oxo-7,8-dihydroguanine mapping in the microRNA transcriptome.
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DOI: 10.1039/d2cc06273a
Abstract: A labeling chemistry-based methodology, APSC-8-oxoGua-seq, is developed to sequence 8-oxoGua in the microRNA transcriptome. N-(3-Azidopropyl)-spermine-5-carboxamide (APSC) is designed for the selective labeling of 8-oxoGua, where its azide facilitates the conjugation of a cleavable linker via… read more here.
Keywords: oxo dihydroguanine; microrna transcriptome; chemical labeling; achieves oxo ... See more keywords