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   Articles with "achilles heel" as a keyword



COVID-19 Coronavirus spike protein analysis for synthetic vaccines, a peptidomimetic antagonist, and therapeutic drugs, and analysis of a proposed achilles’ heel conserved region to minimize probability of escape mutations and drug resistance

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recommendations! Published in 2020 at "Computers in Biology and Medicine"

DOI: 10.1016/j.compbiomed.2020.103749

Abstract: Abstract This paper continues a recent study of the spike protein sequence of the COVID-19 virus (SARS-CoV-2). It is also in part an introductory review to relevant computational techniques for tackling viral threats, using COVID-19… read more here.

Keywords: analysis; spike protein; covid; spike ... See more keywords

Ferrocene-embedded flavonoids targeting the Achilles heel of multidrug-resistant cancer cells through collateral sensitivity.

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recommendations! Published in 2017 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2017.02.064

Abstract: With the aim to develop anticancer agents acting selectively against resistant tumor cells, we investigated ferrocene embedded into chalcone, aurone and flavone skeletons. These compounds were conceived and then investigated based on the concept of… read more here.

Keywords: collateral sensitivity; cancer cells; cancer; resistant cancer ... See more keywords

CBP/Catenin antagonists: Targeting LSCs' Achilles heel.

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recommendations! Published in 2017 at "Experimental hematology"

DOI: 10.1016/j.exphem.2017.04.010

Abstract: Cancer stem cells (CSCs), including leukemia stem cells (LSCs), exhibit self-renewal capacity and differentiation potential and have the capacity to maintain or renew and propagate a tumor/leukemia. The initial isolation of CSCs/LSCs was in adult… read more here.

Keywords: stem cells; leukemia; achilles heel; cbp catenin ... See more keywords

Is autoimmunity the Achilles' heel of cancer immunotherapy?

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recommendations! Published in 2017 at "Nature Medicine"

DOI: 10.1038/nm.4321

Abstract: The emergence of immuno-oncology as the first broadly successful strategy for metastatic cancer will require clinicians to integrate this new pillar of medicine with chemotherapy, radiation, and targeted small-molecule compounds. Of equal importance is gaining… read more here.

Keywords: medicine; immunotherapy; autoimmunity achilles; cancer ... See more keywords

The Achilles’ heel of the Trojan Horse? A systematic evaluation of cefiderocol susceptibility testing

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recommendations! Published in 2025 at "Journal of Antimicrobial Chemotherapy"

DOI: 10.1093/jac/dkaf391

Abstract: Abstract Cefiderocol, an innovative siderophore cephalosporin, presents a novel therapeutic option against a spectrum of multidrug-resistant (MDR) Gram-negative pathogens. Nevertheless, resistance remains a formidable challenge, particularly among metallo-beta-lactamase (MBL)-producing organisms. Accurate antimicrobial susceptibility testing (AST)… read more here.

Keywords: susceptibility testing; susceptibility; cefiderocol; heel trojan ... See more keywords

The Achilles’ heel of left ventricular assist device therapy: right ventricle

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recommendations! Published in 2018 at "Current Opinion in Organ Transplantation"

DOI: 10.1097/mot.0000000000000528

Abstract: Purpose of review Many patients suffer from either persistent right ventricular failure (RVF) at the time of left ventricular assist device (LVAD) or have ongoing symptoms consistent with RVF during chronic mechanical circulatory support. The… read more here.

Keywords: rvf; assist device; ventricular assist; achilles heel ... See more keywords

AI Impermanence: Achilles’ Heel for AI Assessment?

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recommendations! Published in 2025 at "IEEE Access"

DOI: 10.1109/access.2025.3631309

Abstract: Scandals have shown that extant assessment methods (e.g., certifications) cannot cater to the impermanent nature of Artificial Intelligence (AI) systems because of their inherent learning capabilities and adaptability. Current AI assessment methods are only limitedly… read more here.

Keywords: assessment methods; assessment; achilles heel; impermanence achilles ... See more keywords

Lights Toward Adversarial Machine Learning: The Achilles Heel of Artificial Intelligence

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recommendations! Published in 2024 at "IEEE Intelligent Systems"

DOI: 10.1109/mis.2024.3441137

Abstract: Artificial intelligence (AI)-based technologies are starting to be adopted in the industrial world in many different contexts and sectors, from health care to the automotive, from agriculture to the industrial. As such applications operate in… read more here.

Keywords: artificial intelligence; machine learning; heel artificial; achilles heel ... See more keywords
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Identifying and targeting the Achilles heel of a recalcitrant cancer

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recommendations! Published in 2021 at "Science Translational Medicine"

DOI: 10.1126/scitranslmed.abj6946

Abstract: Targeting replication stress response proteins in small cell lung cancer activates the innate immune cGAS-STING pathway leading to augmentation of immunotherapy’s antitumor response. Targeting replication stress response proteins in small cell lung cancer activates the… read more here.

Keywords: response; heel recalcitrant; identifying targeting; cancer ... See more keywords

Targeting the Achilles’ Heel of Bacteria: Different Mechanisms To Break Down the Peptidoglycan Cell Wall during Bacterial Warfare

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recommendations! Published in 2020 at "Journal of Bacteriology"

DOI: 10.1128/jb.00478-20

Abstract: Bacteria commonly live in dense polymicrobial communities and compete for scarce resources. Consequently, they employ a diverse array of mechanisms to harm, inhibit, and kill their competitors. The cell wall is essential for bacterial survival… read more here.

Keywords: targeting achilles; achilles heel; cell wall; cell ... See more keywords

David Oliver: The NHS’s understaffing is its Achilles’ heel

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recommendations! Published in 2017 at "British Medical Journal"

DOI: 10.1136/bmj.j2192

Abstract: I’ve long stopped believing any soundbites about NHS staffing or funding if they come from the Department of Health or Number 10. I’d like to see a truly independent body for all NHS statistics. The… read more here.

Keywords: nhs understaffing; david oliver; understaffing achilles; oliver nhs ... See more keywords