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   Articles with "achilles heel" as a keyword



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COVID-19 Coronavirus spike protein analysis for synthetic vaccines, a peptidomimetic antagonist, and therapeutic drugs, and analysis of a proposed achilles’ heel conserved region to minimize probability of escape mutations and drug resistance

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recommendations! Published in 2020 at "Computers in Biology and Medicine"

DOI: 10.1016/j.compbiomed.2020.103749

Abstract: Abstract This paper continues a recent study of the spike protein sequence of the COVID-19 virus (SARS-CoV-2). It is also in part an introductory review to relevant computational techniques for tackling viral threats, using COVID-19… read more here.

Keywords: analysis; spike protein; covid; spike ... See more keywords
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Ferrocene-embedded flavonoids targeting the Achilles heel of multidrug-resistant cancer cells through collateral sensitivity.

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recommendations! Published in 2017 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2017.02.064

Abstract: With the aim to develop anticancer agents acting selectively against resistant tumor cells, we investigated ferrocene embedded into chalcone, aurone and flavone skeletons. These compounds were conceived and then investigated based on the concept of… read more here.

Keywords: collateral sensitivity; cancer cells; cancer; resistant cancer ... See more keywords
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CBP/Catenin antagonists: Targeting LSCs' Achilles heel.

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recommendations! Published in 2017 at "Experimental hematology"

DOI: 10.1016/j.exphem.2017.04.010

Abstract: Cancer stem cells (CSCs), including leukemia stem cells (LSCs), exhibit self-renewal capacity and differentiation potential and have the capacity to maintain or renew and propagate a tumor/leukemia. The initial isolation of CSCs/LSCs was in adult… read more here.

Keywords: stem cells; leukemia; achilles heel; cbp catenin ... See more keywords
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Is autoimmunity the Achilles' heel of cancer immunotherapy?

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recommendations! Published in 2017 at "Nature Medicine"

DOI: 10.1038/nm.4321

Abstract: The emergence of immuno-oncology as the first broadly successful strategy for metastatic cancer will require clinicians to integrate this new pillar of medicine with chemotherapy, radiation, and targeted small-molecule compounds. Of equal importance is gaining… read more here.

Keywords: medicine; immunotherapy; autoimmunity achilles; cancer ... See more keywords
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The Achilles’ heel of left ventricular assist device therapy: right ventricle

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recommendations! Published in 2018 at "Current Opinion in Organ Transplantation"

DOI: 10.1097/mot.0000000000000528

Abstract: Purpose of review Many patients suffer from either persistent right ventricular failure (RVF) at the time of left ventricular assist device (LVAD) or have ongoing symptoms consistent with RVF during chronic mechanical circulatory support. The… read more here.

Keywords: rvf; assist device; ventricular assist; achilles heel ... See more keywords
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Identifying and targeting the Achilles heel of a recalcitrant cancer

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recommendations! Published in 2021 at "Science Translational Medicine"

DOI: 10.1126/scitranslmed.abj6946

Abstract: Targeting replication stress response proteins in small cell lung cancer activates the innate immune cGAS-STING pathway leading to augmentation of immunotherapy’s antitumor response. Targeting replication stress response proteins in small cell lung cancer activates the… read more here.

Keywords: response; heel recalcitrant; identifying targeting; cancer ... See more keywords
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Targeting the Achilles’ Heel of Bacteria: Different Mechanisms To Break Down the Peptidoglycan Cell Wall during Bacterial Warfare

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recommendations! Published in 2020 at "Journal of Bacteriology"

DOI: 10.1128/jb.00478-20

Abstract: Bacteria commonly live in dense polymicrobial communities and compete for scarce resources. Consequently, they employ a diverse array of mechanisms to harm, inhibit, and kill their competitors. The cell wall is essential for bacterial survival… read more here.

Keywords: targeting achilles; achilles heel; cell wall; cell ... See more keywords
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David Oliver: The NHS’s understaffing is its Achilles’ heel

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recommendations! Published in 2017 at "British Medical Journal"

DOI: 10.1136/bmj.j2192

Abstract: I’ve long stopped believing any soundbites about NHS staffing or funding if they come from the Department of Health or Number 10. I’d like to see a truly independent body for all NHS statistics. The… read more here.

Keywords: nhs understaffing; david oliver; understaffing achilles; oliver nhs ... See more keywords
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The Achilles Heel of Malignant Rhabdoid Tumors.

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recommendations! Published in 2019 at "Cancer research"

DOI: 10.1158/0008-5472.can-19-0990

Abstract: Malignant rhabdoid tumors (MRT) are rare but deadly pediatric tumors characterized by mutations in the SMARCB1/SNF5/INI1/BAF47 gene. Currently, there are no targeted therapies for MRTs. In a previous issue of Cancer Research, Howard and colleagues… read more here.

Keywords: malignant rhabdoid; cancer; heel malignant; achilles heel ... See more keywords
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Is GPNMB the Achilles' Heel of Mo-MDSC While Marking Their Suppressive Activity?

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recommendations! Published in 2018 at "Clinical Cancer Research"

DOI: 10.1158/1078-0432.ccr-18-2334

Abstract: Glycoprotein nonmetastatic B/DC-Hil/Osteoactivin on myeloid-derived suppressor cells impairs T lymphocytes through the binding of Syndecan-4, delineating a new checkpoint pair to be targeted perhaps in combination with PD-1/PD-L1 blockage. See related article by Kobayashi et… read more here.

Keywords: gpnmb achilles; suppressive activity; heel mdsc; achilles heel ... See more keywords
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Calibration: the Achilles heel of predictive analytics

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recommendations! Published in 2019 at "BMC Medicine"

DOI: 10.1186/s12916-019-1466-7

Abstract: BackgroundThe assessment of calibration performance of risk prediction models based on regression or more flexible machine learning algorithms receives little attention.Main textHerein, we argue that this needs to change immediately because poorly calibrated algorithms can… read more here.

Keywords: medicine; calibration achilles; predictive analytics; calibration ... See more keywords