Impaired gating of γ‐ and ε‐AChR respectively causes Escobar syndrome and fast‐channel myasthenia
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51756
Abstract: To dissect the kinetic defects of acetylcholine receptor (AChR) γ subunit variant in an incomplete form of the Escobar syndrome without pterygium and compare it with those of a variant of corresponding residue in the… read more here.
Keywords: achr respectively; achr; gating achr; escobar syndrome ... See more keywords
Differential response to rituximab in anti-AChR and anti-MuSK positive myasthenia gravis patients: a single-center retrospective study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2020.116690
Abstract: BACKGROUND B-cell targeted therapy with rituximab has shown durable response in treating refractory myasthenia gravis (MG). This study compares the response to rituximab between patients with acetylcholine receptor autoantibody positive (AChR+) and muscle-specific kinase autoantibody… read more here.
Keywords: rituximab; achr; response; study ... See more keywords
Are linear AChR epitopes the real culprit in ocular myasthenia gravis?
Sign Up to like & getrecommendations! Published in 2017 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2016.11.021
Abstract: Extraocular muscle weakness occurs in most of the myasthenia gravis (MG) patients and it is often the initial complaint. Approximately 10-20% of MG patients with extraocular muscle weakness display only ocular symptoms and rest of… read more here.
Keywords: generalized muscle; ocular symptoms; muscle; muscle weakness ... See more keywords
Roles of tyrosine kinases and phosphatases in the formation and dispersal of acetylcholine receptor clusters
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135054
Abstract: The formation of acetylcholine receptor (AChR) clusters at the postsynaptic muscle membrane in response to motor innervation is a key event in the development of the neuromuscular junction. The synaptic AChR clustering process is initiated… read more here.
Keywords: dispersal; formation; tyrosine kinases; achr ... See more keywords
AChR antibodies show a complex interaction with human skeletal muscle cells in a transcriptomic study
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DOI: 10.1038/s41598-020-68185-x
Abstract: Acetylcholine receptor (AChR) antibodies are the most important pathogenic marker in patients with myasthenia gravis (MG). The antibodies bind to AChRs on the postsynaptic membrane, and this leads to receptor degradation, destruction, or functional blocking… read more here.
Keywords: skeletal muscle; achr antibodies; muscle cells; human skeletal ... See more keywords
In vitro susceptibility of nonfermenting Gram-negative rods to meropenem-vaborbactam and delafloxacin.
Sign Up to like & getrecommendations! Published in 2023 at "Future microbiology"
DOI: 10.2217/fmb-2021-0278
Abstract: Aim: Meropenem-vaborbactam and delafloxacin activities were not assessed against Achromobacter spp. (Achr), Burkholderia cepacia complex (Bcc) and Stenotrophomonas maltophilia (Smal). Methodology: A total of 106 Achr, 57 Bcc and 100 Smal were tested with gradient diffusion test of meropenem-vaborbactam,… read more here.
Keywords: vaborbactam delafloxacin; achr; meropenem vaborbactam;