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   Articles with "achr" as a keyword



Impaired gating of γ‐ and ε‐AChR respectively causes Escobar syndrome and fast‐channel myasthenia

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recommendations! Published in 2023 at "Annals of Clinical and Translational Neurology"

DOI: 10.1002/acn3.51756

Abstract: To dissect the kinetic defects of acetylcholine receptor (AChR) γ subunit variant in an incomplete form of the Escobar syndrome without pterygium and compare it with those of a variant of corresponding residue in the… read more here.

Keywords: achr respectively; achr; gating achr; escobar syndrome ... See more keywords

Differential response to rituximab in anti-AChR and anti-MuSK positive myasthenia gravis patients: a single-center retrospective study

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recommendations! Published in 2020 at "Journal of the Neurological Sciences"

DOI: 10.1016/j.jns.2020.116690

Abstract: BACKGROUND B-cell targeted therapy with rituximab has shown durable response in treating refractory myasthenia gravis (MG). This study compares the response to rituximab between patients with acetylcholine receptor autoantibody positive (AChR+) and muscle-specific kinase autoantibody… read more here.

Keywords: rituximab; achr; response; study ... See more keywords

Are linear AChR epitopes the real culprit in ocular myasthenia gravis?

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recommendations! Published in 2017 at "Medical hypotheses"

DOI: 10.1016/j.mehy.2016.11.021

Abstract: Extraocular muscle weakness occurs in most of the myasthenia gravis (MG) patients and it is often the initial complaint. Approximately 10-20% of MG patients with extraocular muscle weakness display only ocular symptoms and rest of… read more here.

Keywords: generalized muscle; ocular symptoms; muscle; muscle weakness ... See more keywords
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Roles of tyrosine kinases and phosphatases in the formation and dispersal of acetylcholine receptor clusters

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recommendations! Published in 2020 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2020.135054

Abstract: The formation of acetylcholine receptor (AChR) clusters at the postsynaptic muscle membrane in response to motor innervation is a key event in the development of the neuromuscular junction. The synaptic AChR clustering process is initiated… read more here.

Keywords: dispersal; formation; tyrosine kinases; achr ... See more keywords
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AChR antibodies show a complex interaction with human skeletal muscle cells in a transcriptomic study

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-68185-x

Abstract: Acetylcholine receptor (AChR) antibodies are the most important pathogenic marker in patients with myasthenia gravis (MG). The antibodies bind to AChRs on the postsynaptic membrane, and this leads to receptor degradation, destruction, or functional blocking… read more here.

Keywords: skeletal muscle; achr antibodies; muscle cells; human skeletal ... See more keywords

Comparison of juvenile and adult myasthenia gravis in a French cohort with focus on thymic histology

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-63162-0

Abstract: Myasthenia gravis (MG) is an autoimmune disease characterized by muscle fatigability due to acetylcholine receptor (AChR) autoantibodies. To better characterize juvenile MG (JMG), we analyzed 85 pre- and 132 post-pubescent JMG (with a cutoff age… read more here.

Keywords: thymic histology; achr; histology; myasthenia gravis ... See more keywords

Analysing the effect caused by increasing the molecular volume in M1-AChR receptor agonists and antagonists: a structural and computational study

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recommendations! Published in 2024 at "RSC Advances"

DOI: 10.1039/d3ra07380g

Abstract: M1 muscarinic acetylcholine receptor (M1-AChR), a member of the G protein-coupled receptors (GPCR) family, plays a crucial role in learning and memory, making it an important drug target for Alzheimer's disease (AD) and schizophrenia. M1-AChR… read more here.

Keywords: receptor; effect caused; analysing effect; agonists antagonists ... See more keywords

In vitro susceptibility of nonfermenting Gram-negative rods to meropenem-vaborbactam and delafloxacin.

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recommendations! Published in 2023 at "Future microbiology"

DOI: 10.2217/fmb-2021-0278

Abstract: Aim: Meropenem-vaborbactam and delafloxacin activities were not assessed against Achromobacter spp. (Achr), Burkholderia cepacia complex (Bcc) and Stenotrophomonas maltophilia (Smal). Methodology: A total of 106 Achr, 57 Bcc and 100 Smal were tested with gradient diffusion test of meropenem-vaborbactam,… read more here.

Keywords: vaborbactam delafloxacin; achr; meropenem vaborbactam;

Development of a refined experimental mouse model of myasthenia gravis with anti-acetylcholine receptor antibodies

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recommendations! Published in 2025 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2025.1521382

Abstract: Myasthenia gravis (MG) is an autoimmune disorder primarily caused by autoantibodies that target the acetylcholine receptor (AChR) at the neuromuscular junction (NMJ). The classical experimental autoimmune myasthenia gravis (C-EAMG) mouse model has long been used… read more here.

Keywords: eamg model; acetylcholine receptor; myasthenia gravis; model ... See more keywords