Acidosis-induced metabolic reprogramming in tumor cells enhances the anti-proliferative activity of the PDK inhibitor dichloroacetate.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.12.003
Abstract: Altered metabolic pathways in cancer such as exacerbated glycolytic flux and increased glutamine metabolism are promising targets for anti-cancer therapies. While commonly observed in glycolytic tumors, extracellular acidosis has never been considered as a potential… read more here.
Keywords: acid adapted; metabolic reprogramming; dca; activity ... See more keywords
Survival of acid-adapted and non-adapted Shiga toxin-producing Escherichia coli using an in vitro model
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DOI: 10.1016/j.foodcont.2019.04.009
Abstract: Abstract Shiga toxin-producing Escherichia coli (STEC) are known to adapt and survive acidic conditions. Acid-adaptation also may result in cross-protection against other stressors present in foods, such as reduced water activity (aw), refrigeration conditions, or… read more here.
Keywords: acid adapted; coli o157; o157 stec; non o157 ... See more keywords
Abstract 171: Acid-induced collagen remodeling promotes cancer progress as a result of niche engineering
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DOI: 10.1158/1538-7445.am2018-171
Abstract: Growing tumors are dynamic and nonlinear ecosystems, wherein cancer cells in tumors adapt to their local microenvironment, and these adaptations further modify the environment, inducing more changes. From nascent intraductal neoplasms to a disseminated metastatic… read more here.
Keywords: collagen; acid adapted; microscopy; collagen remodeling ... See more keywords