Recent Advances in Biocatalysis with Chemical Modification and Expanded Amino Acid Alphabet.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.0c01201
Abstract: The two main strategies for enzyme engineering, directed evolution and rational design, have found widespread applications in improving the intrinsic activities of proteins. Although numerous advances have been achieved using these ground-breaking methods, the limited… read more here.
Keywords: acid alphabet; amino acid; chemical modification; recent advances ... See more keywords
Early Selection of the Amino Acid Alphabet Was Adaptively Shaped by Biophysical Constraints of Foldability
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c12987
Abstract: Whereas modern proteins rely on a quasi-universal repertoire of 20 canonical amino acids (AAs), numerous lines of evidence suggest that ancient proteins relied on a limited alphabet of 10 ‘early’ AAs, and that the 10… read more here.
Keywords: amino acids; acid alphabet; alphabet; amino acid ... See more keywords