Bioinspired Fatty Acid Amide‐Based Slippery Oleogels for Shear‐Stable Lubrication
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105528
Abstract: Liquid‐repellent technology is an efficient means of energy‐saving and biofouling avoidance. However, liquid‐repellent surfaces suffer from inefficient lubricant retention under shear flow and fouling problem in marine environment. Here, the authors demonstrate a fatty acid… read more here.
Keywords: lubrication; marine; stable lubrication; acid amide ... See more keywords
Synthesis and evaluation of carbamate derivatives as fatty acid amide hydrolase and monoacylglycerol lipase inhibitors
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DOI: 10.1002/ardp.202200081
Abstract: Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) are the primary catabolic enzymes for endocannabinoids, anandamide (AEA), and 2‐arachidonoyl glycerol. Numerous studies have shown that FAAH and MAGL play an important role in modulating… read more here.
Keywords: faah magl; acid amide; carbamate; fatty acid ... See more keywords
Development and molecular modeling studies of new thiadiazole piperazine urea derivatives as potential fatty acid amide hydrolase inhibitors
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DOI: 10.1002/ardp.202200082
Abstract: A series of novel piperazine urea derivatives with thiadiazole moieties were designed, synthesized, and investigated for their inhibition potential against human fatty acid amide hydrolase (hFAAH). The urea derivatives possessing p‐chlorophenylthiadiazole and benzylpiperazine fragments (19–22)… read more here.
Keywords: amide hydrolase; acid; piperazine urea; acid amide ... See more keywords
Inactivation Mechanism of the Fatty Acid Amide Hydrolase Inhibitor BIA 10‐2474
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DOI: 10.1002/cbic.202200166
Abstract: BIA 10‐2474 is a time‐dependent inhibitor of fatty acid amide hydrolase (FAAH) that was under clinical development for the treatment of neurological conditions when the program was terminated after one subject died and four were… read more here.
Keywords: amide hydrolase; inhibitor; acid amide; bia 2474 ... See more keywords
Discovery of a Potent, Long‐Acting, and CNS‐Active Inhibitor (BIA 10‐2474) of Fatty Acid Amide Hydrolase
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DOI: 10.1002/cmdc.201800393
Abstract: Fatty acid amide hydrolase (FAAH) can be targeted for the treatment of pain associated with various medical conditions. Herein we report the design and synthesis of a novel series of heterocyclic‐N‐carboxamide FAAH inhibitors that have… read more here.
Keywords: acid amide; bia 2474; long acting; fatty acid ... See more keywords
Effects of fatty acid amide hydrolase inhibitor URB597 in a rat model of trauma-induced long-term anxiety
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-5020-7
Abstract: RationaleThe endocannabinoid neurotransmitter, anandamide, has been implicated in the central modulation of stress responses. Previous animal experiments have shown that inhibitors of the anandamide-degrading enzyme, fatty acid amide hydrolase (FAAH), enhance the ability to cope… read more here.
Keywords: acid amide; anxiety; fatty acid; amide hydrolase ... See more keywords
Tetrazolylpropan-2-ones as inhibitors of fatty acid amide hydrolase: Studies on structure-activity relationships and metabolic stability.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.10.021
Abstract: A series of derivatives of 1-(4-octylphenoxy)-3-(2H-tetrazol-2-yl)propan-2-one (3) and 1-(4-octylphenoxy)-3-(1H-tetrazol-1-yl)propan-2-one (4) was synthesized and tested for fatty acid amide hydrolase (FAAH) inhibitory potency and phase I metabolic stability. Introduction of certain substituents like 4-chlorophenyl, 4-methoxycarbonylphenyl and… read more here.
Keywords: acid amide; metabolic stability; fatty acid; amide hydrolase ... See more keywords
A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111953
Abstract: Fatty acid amide hydrolase (FAAH) is an important enzyme creditworthy of hydrolyzing endocannabinoids and related-amidated signalling lipids, discovery of which has pioneered novel arena of pharmacological canvasses to unwrap its curative potency in various diseased… read more here.
Keywords: acid amide; faah; fatty acid; amide hydrolase ... See more keywords
Neuroprotective effects of fatty acid amide hydrolase catabolic enzyme inhibition in a HIV-1 Tat model of neuroAIDS
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.08.013
Abstract: ABSTRACT The HIV‐1 transactivator of transcription (Tat) is a neurotoxin involved in the pathogenesis of HIV‐1 associated neurocognitive disorders (HAND). The neurotoxic effects of Tat are mediated directly via AMPA/NMDA receptor activity and indirectly through… read more here.
Keywords: tat mediated; acid amide; hiv; inhibition ... See more keywords
Fatty Acid Amide Hydrolases: An Expanded Capacity for Chemical Communication?
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DOI: 10.1016/j.tplants.2019.11.002
Abstract: Fatty acid amide hydrolase (FAAH) is an enzyme that belongs to the amidase signature (AS) superfamily and is widely distributed in multicellular eukaryotes. FAAH hydrolyzes lipid signaling molecules - namely, N-acylethanolamines (NAEs) - which terminates… read more here.
Keywords: amide hydrolases; faah; acid amide; communication ... See more keywords
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01084
Abstract: Cannabinoid type 2 receptor (CB2R), belonging to the endocannabinoid system, is overexpressed in pathologies characterized by inflammation, and its activation counteracts inflammatory states. Fatty acid amide hydrolase (FAAH) is an enzyme responsible for the degradation… read more here.
Keywords: amide hydrolase; adamantyl benzamides; anti inflammatory; acid amide ... See more keywords