QSAR study on 4-alkynyldihydrocinnamic acid analogs as free fatty acid receptor 1 agonists and antidiabetic agents: Rationales to improve activity
Sign Up to like & getrecommendations! Published in 2019 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2014.11.047
Abstract: Abstract The free fatty acid receptor 1 (FFAR1) is a class A G-protein coupled receptor and a validated target to develop antidiabetic drugs. The present work describes the quantitative structure–activity relationship (QSAR) study of a… read more here.
Keywords: acid analogs; free fatty; alkynyldihydrocinnamic acid; activity ... See more keywords
1,2,3-Triazole-based kojic acid analogs as potent tyrosinase inhibitors: Design, synthesis and biological evaluation.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.10.069
Abstract: A series of kojic acid-derived compounds 6a-p bearing aryloxymethyl-1H-1,2,3-triazol-1-yl moiety were designed by modifying primary alcoholic group of kojic acid as tyrosinase inhibitors. The target compounds 6a-p were synthesized via click reaction. All compounds showed… read more here.
Keywords: analogs potent; based kojic; tyrosinase inhibitors; kojic acid ... See more keywords
Gambogic Acid and Its Analogs Inhibit Gap Junctional Intercellular Communication
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.00814
Abstract: Gap junctions (GJs) are intercellular channels composed of connexins. Cellular molecules smaller than 1 kDa can diffuse through GJs by a process termed gap junctional intercellular communication (GJIC), which plays essential roles in various pathological… read more here.
Keywords: communication; junctional intercellular; intercellular communication; gap junctional ... See more keywords
Ursolic Acid Analogs as Potential Therapeutics for Cancer
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DOI: 10.3390/molecules27248981
Abstract: Ursolic acid (UA) is a pentacyclic triterpene isolated from a large variety of vegetables, fruits and many traditional medicinal plants. It is a structural isomer of Oleanolic Acid. The medicinal application of UA has been… read more here.
Keywords: acid analogs; therapeutics cancer; ursolic acid; analogs potential ... See more keywords