Nucleic Acid Aptamers for Pesticides, Toxins, and Biomarkers in Agriculture.
Sign Up to like & getrecommendations! Published in 2022 at "ChemPlusChem"
DOI: 10.1002/cplu.202200230
Abstract: Nucleic acid aptamers are short single-stranded DNA/RNA (ssDNA/RNA) oligonucleotides that can selectively bind to the targets. They are widely used in medicine, biosensing, and diagnostic assay. They have also been identified and extensively used for… read more here.
Keywords: aptamers pesticides; toxins biomarkers; pesticides toxins; acid aptamers ... See more keywords
Identification of nucleic acid aptamers against lactate dehydrogenase via SELEX and high-throughput sequencing
Sign Up to like & getrecommendations! Published in 2021 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-021-03397-2
Abstract: Nucleic acid aptamers are small fragments of DNA or RNA molecules binding specifically to targets, which can be obtained through in vitro screening via systematic evolution of ligands by exponential enrichment (SELEX). Lactate dehydrogenase (LDH)… read more here.
Keywords: throughput sequencing; ldh; lactate dehydrogenase; nucleic acid ... See more keywords
Nucleic acid aptamers in diagnosis of colorectal cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Biochimie"
DOI: 10.1016/j.biochi.2018.09.009
Abstract: Nucleic acid aptamers are promising recognition ligands for diagnostic applications. They are short DNA or RNA molecules isolated from large random libraries through the Systematic Evolution of Ligands by EXponential enrichment (SELEX) procedure. These molecules,… read more here.
Keywords: aptamers diagnosis; colorectal cancer; cancer; nucleic acid ... See more keywords
Challenges with osmolytes as inhibitors of protein aggregation: Can nucleic acid aptamers provide an answer?
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2016.05.014
Abstract: Protein aggregation follows some common motifs. Whether in the formation of inclusion bodies in heterologous overexpression systems or inclusions in protein conformational diseases, or aggregation during storage or transport of protein formulations, aggregates form cross… read more here.
Keywords: aggregation; nucleic acid; acid aptamers; protein aggregation ... See more keywords
Characterization and purification via nucleic acid aptamers of a novel esterase from the metagenome of paper mill wastewater sediments.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.02.319
Abstract: A new esterase gene est906 was identified from paper mill wastewater sediments via a function-based metagenomic approach. The gene encoded a protein of 331 amino acids, that shared 86% homology with known esterases. Based on… read more here.
Keywords: mill wastewater; paper mill; wastewater sediments; nucleic acid ... See more keywords
Recent Progress and Opportunities for Nucleic Acid Aptamers
Sign Up to like & getrecommendations! Published in 2021 at "Life"
DOI: 10.3390/life11030193
Abstract: Coined three decades ago, the term aptamer and directed evolution have now reached their maturity. The concept that nucleic acid could modulate the activity of target protein as ligand emerged from basic science studies of… read more here.
Keywords: opportunities nucleic; recent progress; progress opportunities; nucleic acid ... See more keywords
Hybrid-Type SELEX for the Selection of Artificial Nucleic Acid Aptamers Exhibiting Cell Internalization Activity
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13060888
Abstract: Nucleic acid aptamers have attracted considerable attention as next-generation pharmaceutical agents and delivery vehicles for small molecule drugs and therapeutic oligonucleotides. Chemical modification is an effective approach for improving the functionality of aptamers. However, the… read more here.
Keywords: artificial nucleic; hybrid type; acid; cell ... See more keywords
Bioimaging Nucleic-Acid Aptamers with Different Specificities in Human Glioblastoma Tissues Highlights Tumoral Heterogeneity
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DOI: 10.3390/pharmaceutics14101980
Abstract: Nucleic-acid aptamers are of strong interest for diagnosis and therapy. Compared with antibodies, they are smaller, stable upon variations in temperature, easy to modify, and have higher tissue-penetration abilities. However, they have been little described… read more here.
Keywords: heterogeneity; glioblastoma; human glioblastoma; acid aptamers ... See more keywords