Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00338
Abstract: As specific inhibitors of the gastric proton pump, responsible for gastric acidification, K+-competitive acid blockers (P-CABs) have recently been utilized in the clinical treatment of gastric acid-related diseases in Asia. However, as these compounds have… read more here.
Keywords: acid blockers; proton pump; gastric proton; competitive acid ... See more keywords
Factors affecting the Gut Microbiome in Pediatric Intestinal Failure.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of pediatric gastroenterology and nutrition"
DOI: 10.1097/mpg.0000000000003828
Abstract: BACKGROUND There is little data on gut microbiome and various factors that lead to dysbiosis in pediatric intestinal failure (PIF). This study aimed to characterize gut microbiome in PIF and determine factors that may affect… read more here.
Keywords: intestinal failure; acid blockers; diversity; gut microbiome ... See more keywords
Detection of Several Homologous MicroRNAs by a Single Smart Probe System Consisting of Linear Nucleic Acid Blockers
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24203691
Abstract: We report a universal smart probe (SP) that is capable of detecting several homologous let-7 microRNAs (miRNAs). While the SP is complementary to let-7a, and therefore, strongly binds to this target, due to sequence homology,… read more here.
Keywords: smart probe; probe; homologous micrornas; acid blockers ... See more keywords