Binding mechanism of anacardic acid, carnosol and garcinol with PCAF: A comprehensive study using molecular docking and molecular dynamics simulations and binding free energy analysis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30400
Abstract: The p300/CBP associated factor bromodomain (PCAF Brd) is emerged as one of the promising target proteins for different types of cancers. PCAF is one among the histone acetyltransferase enzymes which involved in the regulation of… read more here.
Keywords: garcinol; acid carnosol; energy; anacardic acid ... See more keywords
Structures and biological activities of new carnosic acid- and carnosol-related compounds generated by heat treatment of rosemary
Sign Up to like & getrecommendations! Published in 2019 at "Phytochemistry Letters"
DOI: 10.1016/j.phytol.2019.01.005
Abstract: Abstract Carnosic acid (CA) and carnosol (CS) are components of rosemary reported to possess antioxidative and peroxisome proliferator-activated receptor gamma (PPARĪ³) transcriptional activities that are useful for preventing metabolic disorders. The aims of this study… read more here.
Keywords: related compounds; structures biological; acid carnosol; carnosic acid ... See more keywords
Carnosic Acid and Carnosol Display Antioxidant and Anti-Prion Properties in In Vitro and Cell-Free Models of Prion Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11040726
Abstract: Prion diseases are transmissible encephalopathies associated with the conversion of the physiological form of the prion protein (PrPC) to the disease-associated (PrPSc). Despite intense research, no therapeutic or prophylactic agent is available. The catechol-type diterpene… read more here.
Keywords: prion; prion diseases; acid carnosol; cell free ... See more keywords
Anti-Inflammatory Therapeutic Mechanisms of Natural Products: Insight from Rosemary Diterpenes, Carnosic Acid and Carnosol
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11020545
Abstract: Carnosic acid (CA) and carnosol (CAR) are two major diterpenes of the rosemary plant (Rosmarinus officinalis). They possess a phenolic structural moiety and are endowed with the power to remove cellular reactive oxygen species (ROS)… read more here.
Keywords: inflammatory therapeutic; acid carnosol; natural products; anti inflammatory ... See more keywords
Carnosic Acid and Carnosol Activate AMPK, Suppress Expressions of Gluconeogenic and Lipogenic Genes, and Inhibit Proliferation of HepG2 Cells
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22084040
Abstract: Carnosic acid (CA), carnosol (CL) and rosmarinic acid (RA), components of the herb rosemary, reportedly exert favorable metabolic actions. This study showed that both CA and CL, but not RA, induce significant phosphorylation of AMP-dependent… read more here.
Keywords: hepg2; proliferation; ampk; acid carnosol ... See more keywords