Skin inflammation and impaired adipogenesis in a mouse model of acid ceramidase deficiency
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12552
Abstract: Acid ceramidase catalyzes the degradation of ceramide into sphingosine and a free fatty acid. Acid ceramidase deficiency results in lipid accumulation in many tissues and leads to the development of Farber disease (FD). Typical manifestations… read more here.
Keywords: skin; ceramidase deficiency; acid ceramidase; mouse ... See more keywords
Histotype-specific analysis of acid ceramidase expression in ovarian cancer
Sign Up to like & getrecommendations! Published in 2020 at "Virchows Archiv"
DOI: 10.1007/s00428-019-02728-0
Abstract: Acid ceramidase (ASAH1) is a key player in sphingolipid metabolism and signaling. It has prognostic value for several cancers, but histotype-specific analyses of ovarian cancer are not yet available. We used three retrospective TMA cohorts… read more here.
Keywords: analysis; expression; ovarian cancer; cancer ... See more keywords
Zebrafish acid ceramidase: Expression in Pichia pastoris GS115and biochemical characterization.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.10.222
Abstract: Acid ceramidase (N-acylsphingosine deacylase EC 3.5.1.23; AC) catalyzes the hydrolysis of ceramide into sphingosine (SPH) and free fatty acid. Zebrafish acid ceramidase (AC) has 60% homology with the human AC). Mutations in the human AC… read more here.
Keywords: characterization; zebrafish acid; pichia pastoris; acid ceramidase ... See more keywords
Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01723
Abstract: Human acid ceramidase (AC) is a lysosomal cysteine amidase, which has received a great deal of interest in recent years as a potential target for the development of new therapeutics against melanoma and glioblastoma tumors.… read more here.
Keywords: inhibition; carmofur; molecular mechanism; ceramidase ... See more keywords
Hepatic pathology and altered gene transcription in a murine model of acid ceramidase deficiency
Sign Up to like & getrecommendations! Published in 2019 at "Laboratory Investigation"
DOI: 10.1038/s41374-019-0271-4
Abstract: Farber disease (FD) is a rare lysosomal storage disorder (LSD) characterized by systemic ceramide accumulation caused by a deficiency in acid ceramidase (ACDase). In its classic form, FD manifests with painful lipogranulomatous nodules in extremities… read more here.
Keywords: gene transcription; pathology; altered gene; gene ... See more keywords
Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07606-w
Abstract: Acid ceramidase (AC) is a lysosomal cysteine hydrolase that catalyzes the conversion of ceramide into fatty acid and sphingosine. This reaction lowers intracellular ceramide levels and concomitantly generates sphingosine used for sphingosine-1-phosphate (S1P) production. Since… read more here.
Keywords: melanoma; ablation; melanoma cells; cancer initiating ... See more keywords
High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2150183
Abstract: Abstract Ceramide has a key role in the regulation of cellular senescence and apoptosis. As Ceramide levels are lowered by the action of acid ceramidase (AC), abnormally expressed in various cancers, the identification of AC… read more here.
Keywords: discovery novel; acid ceramidase; high throughput; ceramidase ... See more keywords
Anticancer effect of acid ceramidase inhibitor ceranib-2 in human breast cancer cell lines MCF-7, MDA MB-231 by the activation of SAPK/JNK, p38 MAPK apoptotic pathways, inhibition of the Akt pathway, downregulation of ER&agr;
Sign Up to like & getrecommendations! Published in 2018 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000000566
Abstract: Acid ceramidase is the key enzyme of the ceramide metabolic pathway, which plays a vital role in regulating ceramide – sphingosine-1-phosphate rheostat. Ceramide acts as a proapoptotic molecule, but its metabolite sphingosine-1-phosphate, in contrast, signals… read more here.
Keywords: breast; cell lines; ceranib; cancer ... See more keywords
The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.03.08.483432
Abstract: Acid ceramidase (Ac) is part of the sphingolipid metabolism and responsible for the degradation of ceramide. As bioactive molecule, ceramide is involved in the regulation of many cellular processes. However, the impact of cell-intrinsic Ac… read more here.
Keywords: acid ceramidase; plasmodium; infection; yoelii ... See more keywords
Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.202001-0180oc
Abstract: Rationale: In cystic fibrosis the major cause of morbidity and mortality is lung disease characterized by inflammation and infection. The influence of sphingolipid metabolism is poorly understood with a lack of studies using human airway… read more here.
Keywords: acid ceramidase; cystic fibrosis; fibrosis; infection ... See more keywords
Molecular mechanism of inhibition of acid ceramidase by carmofur.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medicinal Chemistry"
DOI: 10.2210/pdb6mhm/pdb
Abstract: Human acid ceramidase (AC) is a lysosomal cysteine amidase, which has received a great deal of interest in recent years as a potential target for the development of new therapeutics against melanoma and glioblastoma tumors.… read more here.
Keywords: acid ceramidase; carmofur; ceramidase; inhibition ... See more keywords