Stereoselective Syntheses of Masked β-Amino Acid Containing Phthalides
Sign Up to like & getrecommendations! Published in 2022 at "Helvetica chimica acta"
DOI: 10.1002/hlca.202200110
Abstract: We herein report a protocol for the asymmetric aldol-initiated cascade addition of isoxazolidin-5-ones to ortho-cyanobenzaldehydes by using Takemoto’s bifunctional organocatalyst. This approach allows for the synthesis of various novel β2,2-amino acid-phthalide conjugates with good enantio-… read more here.
Keywords: acid containing; masked amino; syntheses masked; acid ... See more keywords
Arachidonic acid‐containing phosphatidylcholine characterized by consolidated plasma and liver lipidomics as an early onset marker for tamoxifen‐induced hepatic phospholipidosis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3442
Abstract: Lipid profiling has emerged as an effective approach to not only screen disease and drug toxicity biomarkers but also understand their underlying mechanisms of action. Tamoxifen, a widely used antiestrogenic agent for adjuvant therapy against… read more here.
Keywords: plasma liver; tamoxifen induced; liver; arachidonic acid ... See more keywords
Molecular design of a high-performance polymeric carrier for delivery of a variety of boronic acid-containing drugs.
Sign Up to like & getrecommendations! Published in 2020 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2020.12.015
Abstract: Because of their many useful and unique properties, boronic acids are well suited for biomedical applications such as antitumor chemotherapy and boron neutron capture therapy (BNCT). Bortezomib, a boronic acid derivative, has drawn a lot… read more here.
Keywords: containing drugs; molecular design; polymeric carrier; acid ... See more keywords
Determination of up to twenty carboxylic acid containing compounds in clinically relevant matrices by o-benzylhydroxylamine derivatization and liquid chromatography-tandem mass spectrometry.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2021.114450
Abstract: Carboxylic acid containing compounds (R-COOH) are involved in a large number of biological processes and they are relevant for several pathological processes such as neurodegeneration or cancer. Comprehensive methodologies for the quantitative determination of R-COOH… read more here.
Keywords: containing compounds; determination; carboxylic acid; derivatization ... See more keywords
Acyl Glucuronide and Coenzyme A Thioester Metabolites of Carboxylic Acid-Containing Drug Molecules: Layering Chemistry with Reactive Metabolism and Toxicology.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00188
Abstract: Glucuronidation and CoA (coenzyme A) conjugation are common pathways for the elimination of carboxylic acid-containing drug molecules. In some instances, these biotransformations have been associated with toxicity (such as idiosyncratic hepatic injury, renal impairment, hemolytic… read more here.
Keywords: acid containing; carboxylic acid; toxicology; chemistry ... See more keywords
Nyuzenamide C, an Antiangiogenic Epoxy Cinnamic Acid-Containing Bicyclic Peptide from a Riverine Streptomyces sp.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.1c00837
Abstract: A new nonribosomal peptide, nyuzenamide C (1), was discovered from riverine sediment-derived Streptomyces sp. DM14. Comprehensive analysis of the spectroscopic data of nyuzenamide C (1) revealed that 1 has a bicyclic backbone composed of six… read more here.
Keywords: acid containing; antiangiogenic epoxy; acid; cinnamic acid ... See more keywords
Biosynthesis of thiocarboxylic acid-containing natural products
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04747-y
Abstract: Thiocarboxylic acid-containing natural products are rare and their biosynthesis and biological significance remain unknown. Thioplatensimycin (thioPTM) and thioplatencin (thioPTN), thiocarboxylic acid congeners of the antibacterial natural products platensimycin (PTM) and platencin (PTN), were recently discovered.… read more here.
Keywords: biosynthesis; natural products; containing natural; thiocarboxylic acid ... See more keywords
Pathway to malonic acid-containing metabolites
Sign Up to like & getrecommendations! Published in 2018 at "Nature Catalysis"
DOI: 10.1038/s41929-018-0191-5
Abstract: A crucial malonic acid moiety in the antibiotic malonomycin has been shown to be installed by a bacterial vitamin K-dependent (VKD) carboxylase orthologue. read more here.
Keywords: malonic acid; pathway malonic; containing metabolites; acid ... See more keywords
Inorganic perovskite engineering through incorporation of a carboxylic acid containing ligand for performance enhancement in perovskite light-emitting diodes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Materials Chemistry C"
DOI: 10.1039/c9tc04834k
Abstract: A perovskite engineering strategy of incorporating a carboxylic acid containing ligand is proposed to enhance device performance of perovskite LEDs. read more here.
Keywords: containing ligand; carboxylic acid; perovskite engineering; acid containing ... See more keywords
Intake of arachidonic acid-containing lipids in adult humans: dietary surveys and clinical trials
Sign Up to like & getrecommendations! Published in 2019 at "Lipids in Health and Disease"
DOI: 10.1186/s12944-019-1039-y
Abstract: Long-chain polyunsaturated fatty acids (LCPUFAs) have important roles in physiological homeostasis. Numerous studies have provided extensive information about the roles of n-3 LCPUFA, such as docosahexaenoic acid and eicosapentaenoic acid. Arachidonic acid (ARA) is one… read more here.
Keywords: intake arachidonic; arachidonic acid; acid; acid containing ... See more keywords
Growing impact of sialic acid-containing glycans in future drug discovery.
Sign Up to like & getrecommendations! Published in 2023 at "Carbohydrate research"
DOI: 10.2139/ssrn.4341534
Abstract: In nature, almost all cells are covered with a complex array of glycan chain namely sialic acids or nuraminic acids, a negatively charged nine carbon sugars which is considered for their great therapeutic importance since… read more here.
Keywords: acid containing; containing glycans; future drug; growing impact ... See more keywords