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Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25467
Abstract: Children with aromatic l‐amino acid decarboxylase (AADC) deficiency suffer from severe motor dysfunction. Restoration of dopamine levels in the putamen by gene therapy has led to significant improvement in motor function. This study explored brain…
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Keywords:
acid decarboxylase;
aromatic amino;
amino acid;
gene therapy ... See more keywords
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Published in 2023 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.202200064
Abstract: γ‐Aminobutyric acid (GABA) is a kind of non‐proteinogenic amino acid which is highly soluble in water and widely used in the food and pharmaceutical industries. Enzymatic conversion is an efficient method to produce GABA, whereby…
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Keywords:
practical application;
gad;
escherichia coli;
acid decarboxylase ... See more keywords
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Published in 2019 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.12800
Abstract: Glutamic acid decarboxylase (GAD) antibodies (ab) have been associated with rare disorders, such as Stiff-person syndrome, limbic encephalitis, cerebellar ataxia, and temporal lobe epilepsy. Other systemic autoimmune disorders have been linked to antiGAD ab, among…
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Keywords:
glutamic acid;
electrographic seizures;
acid decarboxylase;
supporting information ... See more keywords
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Published in 2023 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13685
Abstract: Aromatic l‐amino acid decarboxylase deficiency (AADCD) is a rare, early‐onset, dyskinetic encephalopathy mostly reflecting a defective synthesis of brain dopamine and serotonin. Intracerebral gene delivery (GD) provided a significant improvement among AADCD patients (mean age,…
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Keywords:
acid decarboxylase;
decarboxylase deficiency;
amino acid;
aromatic amino ... See more keywords
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Published in 2020 at "Movement Disorders"
DOI: 10.1002/mds.27993
Abstract: As Parkinson's disease progresses, levodopa treatment loses efficacy, partly through the loss of the endogenous dopamine‐synthesizing enzyme L‐amino acid decarboxylase (AADC). In the phase I PD‐1101 study, putaminal administration of VY‐AADC01, an investigational adeno‐associated virus…
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Keywords:
acid decarboxylase;
amino acid;
disease;
parkinson disease ... See more keywords
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Published in 2020 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1143
Abstract: Aromatic L‐amino acid decarboxylase deficiency (AADCD) is a rare, autosomal recessive inherited disorder which is characterized by neurological and vegetative symptoms. To date, only 130 patients with AADCD have been reported worldwide.
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Keywords:
acid decarboxylase;
aromatic amino;
amino acid;
decarboxylase deficiency ... See more keywords
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Published in 2020 at "Neurological Sciences"
DOI: 10.1007/s10072-020-04466-7
Abstract: Background Glutamic acid decarboxylase (GAD) is an intracellular enzyme, which is widely expressed in central nervous system (CNS), pancreas, and other organs. GAD antibodies (GAD-Abs) are linked to various neurological disorders. However, the significance of…
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Keywords:
gad abs;
neurocritical patients;
glutamic acid;
acid decarboxylase ... See more keywords
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Published in 2018 at "Journal of Plant Biochemistry and Biotechnology"
DOI: 10.1007/s13562-018-0466-6
Abstract: The phenolic acid decarboxylase (PAD) is a 44 kDa homodimeric, thermolabile and acid-resistant enzyme that some bacteria have developed as a detoxification system against phenolic acids produced by plants. It seems that the specificity of the…
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Keywords:
related bacteria;
molecular dynamics;
acid decarboxylase;
lactobacillus plantarum ... See more keywords
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Published in 2018 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2018.02.008
Abstract: Reversible benzoic acid decarboxylases are versatile biocatalysts by taking advantage of both decarboxylation and carboxylation reactions, especially for the biocatalytic Kolbe-Schmitt reaction. In the course of developing a benzoic acid decarboxylase tool-box, a putative benzoic…
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Keywords:
acid;
acid decarboxylase;
reaction;
dihydroxybenzoic acid ... See more keywords
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Published in 2018 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2018.01.013
Abstract: Several neurological disorders have been described in patients with autoimmunity associated with GAD antibodies. Among these disorders, nystagmus and oculomotor dysfunction are increasingly recognized, although they have been rarely reported isolated or as the main…
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Keywords:
glutamic acid;
associated glutamic;
gad antibodies;
acid decarboxylase ... See more keywords
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Published in 2021 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c04091
Abstract: Salicylic acid (SA) decarboxylase from Trichosporon moniliiforme (TmSdc), which reversibly catalyses the decarboxylation of SA to yield phenol, is of significant interest because of its potential for the production of benzoic acid derivatives under environmentally…
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Keywords:
salicylic acid;
decarboxylase;
recognition;
acid decarboxylase ... See more keywords