Insights into retinoic acid deficiency and the induction of craniofacial malformations and microcephaly in fetal alcohol spectrum disorder
Sign Up to like & getrecommendations! Published in 2019 at "genesis"
DOI: 10.1002/dvg.23278
Abstract: Fetal Alcohol Spectrum Disorder (FASD) is a set of neurodevelopmental malformations caused by maternal consumption of alcohol during pregnancy. FASD sentinel facial features are unique to the disorder, and microcephaly is common in severe forms… read more here.
Keywords: craniofacial malformations; acid deficiency; retinoic acid; deficiency ... See more keywords
FADS2 inhibition in essential fatty acid deficiency induces hepatic lipid accumulation via impairment of very low-density lipoprotein (VLDL) secretion.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.01.064
Abstract: Fatty acid desaturase 2 (FADS2) is responsible for the first desaturation reaction in the synthesis of highly unsaturated fatty acids (HUFAs), such as arachidonic acid (20:4n-6) and eicosapentaenoic acid (20:5n-3), and is involved in Mead… read more here.
Keywords: secretion; acid deficiency; fatty acid; essential fatty ... See more keywords
Retinoic Acid Deficiency Underlies the Etiology of Midfacial Defects
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DOI: 10.1177/00220345211062049
Abstract: Embryonic craniofacial development depends on the coordinated outgrowth and fusion of multiple facial primordia, which are populated with cranial neural crest cells and covered by the facial ectoderm. Any disturbance in these developmental events, their… read more here.
Keywords: acid deficiency; etiology; underlies etiology; retinoic acid ... See more keywords
Early Life Stage Folic Acid Deficiency Delays the Neurobehavioral Development and Cognitive Function of Rat Offspring by Hindering De Novo Telomere Synthesis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23136948
Abstract: Early life stage folate status may influence neurodevelopment in offspring. The developmental origin of health and disease highlights the importance of the period of the first 1000 days (from conception to 2 years) of life.… read more here.
Keywords: life stage; acid deficiency; early life; folic acid ... See more keywords