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   Articles with "acid degradable" as a keyword



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Imidazole-Mediated Dual Location Disassembly of Acid-Degradable Intracellular Drug Delivery Block Copolymer Nanoassemblies.

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recommendations! Published in 2021 at "Macromolecular rapid communications"

DOI: 10.1002/marc.202100262

Abstract: Acid-degradable (or acid-cleavable) polymeric nanoassemblies have witnessed significant progress in anti-cancer drug delivery. However, conventional nanoassemblies designed with acid-cleavable linkages at a single location have several challenges, such as, sluggish degradation, undesired aggregation of degraded… read more here.

Keywords: drug; drug delivery; location; acid degradable ... See more keywords
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SiRNA‐mediated in vivo gene knockdown by acid‐degradable cationic nanohydrogel particles

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recommendations! Published in 2017 at "Journal of Controlled Release"

DOI: 10.1016/j.jconrel.2016.12.006

Abstract: Abstract Cationic nanohydrogel particles have become an attractive tool for systemic siRNA delivery, but improvement of their in vivo tolerance is desirable, especially to prevent potential long term side effects by tissue and cellular accumulation.… read more here.

Keywords: nanohydrogel particles; degradable cationic; gene knockdown; cationic nanohydrogel ... See more keywords
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Acid-degradable poly(ortho ester urethanes) copolymers for potential drug carriers: Preparation, characterization, in vitro and in vivo evaluation

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recommendations! Published in 2017 at "Polymer"

DOI: 10.1016/j.polymer.2017.02.079

Abstract: Abstract Herein, acid-degradable poly(ortho ester urethanes) (POEUs) were synthesized via polycondensation between an acid-labile ortho ester diamine and active esters of poly(e-caprolactone) (PCL) diols with different molecular weights. The POEUs nanoparticles were easily fabricated using… read more here.

Keywords: ortho ester; poly ortho; acid degradable; acid ... See more keywords
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Reprocessable Acid-Degradable Polycarbonate Vitrimers

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recommendations! Published in 2018 at "Macromolecules"

DOI: 10.1021/acs.macromol.7b02299

Abstract: Vitrimers are cross-linked polymer networks containing linkages that undergo thermally activated, associative exchange reactions, such that the cross-link density and overall network connectivity are preserved. Polycarbonates are industrially relevant polymers that, to our knowledge, have… read more here.

Keywords: polycarbonate; polycarbonate vitrimers; degradable polycarbonate; reprocessable acid ... See more keywords

Supermolecule—Drug Conjugates Based on Acid-Degradable Polyrotaxanes for pH-Dependent Intracellular Release of Doxorubicin

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recommendations! Published in 2023 at "Molecules"

DOI: 10.3390/molecules28062517

Abstract: Doxorubicin (DOX)-conjugated acid-degradable polyrotaxanes (PRXs) were designed as supramolecular drug carriers capable of releasing drugs in acidic cellular environments. Acid-degradable PRXs composed of α-cyclodextrin (α-CD) as a cyclic molecule, poly(ethylene glycol) (PEG) as a polymer… read more here.

Keywords: acid degradable; modified cds; degradable polyrotaxanes; intracellular release ... See more keywords
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Calcium phosphate-adsorbable and acid-degradable carboxylated polyrotaxane consisting of β-cyclodextrins suppresses osteoclast resorptive activity.

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recommendations! Published in 2022 at "Dental materials journal"

DOI: 10.4012/dmj.2021-331

Abstract: Recently, the potential of β-cyclodextrin-thread acid-degradable polyrotaxane (AdPRX) has been emphasized as a therapeutic agent for cholesterol-related metabolic disorders. In this study, we investigated whether carboxymethyl carbamate-modified AdPRX (CMC-AdPRX) can be used for adsorption to… read more here.

Keywords: calcium phosphate; adprx; acid degradable; cmc adprx ... See more keywords
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Acid-degradable Dextran as an Image Guided siRNA Carrier for COX-2 Downregulation

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recommendations! Published in 2018 at "Theranostics"

DOI: 10.7150/thno.21052

Abstract: Purpose: Effective in vivo delivery of siRNA to silence genes is a highly sought-after goal in the treatment of multiple diseases. Cyclooxygenase-2 (COX-2) is a major mediator of inflammation and its effective and specific downregulation… read more here.

Keywords: sirna carrier; dextran; degradable dextran; downregulation ... See more keywords