Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids.
Sign Up to like & getrecommendations! Published in 2019 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2018.10.003
Abstract: Clostridium scindens biotransforms primary bile acids into secondary bile acids, and is correlated with inhibition of Clostridium difficile growth in vivo. The aim of the current study was to determine how C. scindens regulates C. difficile growth in vitro… read more here.
Keywords: clostridium difficile; bile acids; acid dehydroxylating; secondary bile ... See more keywords
Metabolism of Oxo-Bile Acids and Characterization of Recombinant 12α-Hydroxysteroid Dehydrogenases from Bile Acid 7α-Dehydroxylating Human Gut Bacteria
Sign Up to like & getrecommendations! Published in 2018 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.00235-18
Abstract: ABSTRACT Bile acids are important cholesterol-derived nutrient signaling hormones, synthesized in the liver, that act as detergents to solubilize dietary lipids. Bile acid 7α-dehydroxylating gut bacteria generate the toxic bile acids deoxycholic acid and lithocholic… read more here.
Keywords: bile acids; acid dehydroxylating; gut bacteria; acid ... See more keywords