Lipid Nanoparticles for Broad‐Spectrum Nucleic Acid Delivery
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202101391
Abstract: Lipid nanoparticles (LNPs) are the most advanced nonviral modality for nucleic acid (NA) delivery, and have recently gained enormous attention in the fields of RNA therapeutics and vaccine development. Here, ionizable adamantane‐based lipidoids named XMaNs,… read more here.
Keywords: lipid nanoparticles; delivery; acid delivery; nanoparticles broad ... See more keywords
Molecular Chameleon Carriers for Nucleic Acid Delivery: The Sweet Spot Between Lipoplexes and Polyplexes.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202211105
Abstract: Taking advantage of effective intracellular delivery mechanisms of both cationizable lipids and polymers, highly potent double pH-responsive nucleic acid carriers were generated by combining at least two lipo amino fatty acids (LAFs) as hydrophobic cationizable… read more here.
Keywords: chameleon carriers; molecular chameleon; nucleic acid; acid delivery ... See more keywords
Nanoparticles for vaccine and gene therapy: Overcoming the barriers to nucleic acid delivery
Sign Up to like & getrecommendations! Published in 2022 at "Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology"
DOI: 10.1002/wnan.1809
Abstract: Abstract Nucleic acid therapeutics can be used to control virtually every aspect of cell behavior and therefore have significant potential to treat genetic disorders, infectious diseases, and cancer. However, while clinically approved to treat a… read more here.
Keywords: nucleic acids; nucleic acid; acid delivery; delivery ... See more keywords
Tunability of Biodegradable Poly(amine- co-ester) Polymers for Customized Nucleic Acid Delivery and Other Biomedical Applications.
Sign Up to like & getrecommendations! Published in 2018 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.8b00997
Abstract: Gene therapy promises to treat diseases that arise from genetic abnormalities by correcting the underlying cause of the disease rather than treating the associated symptoms. Successful transfer of nucleic acids into cells requires efficient delivery… read more here.
Keywords: acid delivery; delivery; amine ester; nucleic acid ... See more keywords
Developing a Ready-to-Use Lipid Nanoparticle Technology for Nucleic Acid Delivery Based on Deep Eutectic Solvents.
Sign Up to like & getrecommendations! Published in 2024 at "Nano letters"
DOI: 10.1021/acs.nanolett.4c04665
Abstract: Microfluidic technology has emerged as a prevalent tool to produce lipid nanoparticles (LNPs) for nucleic acid delivery. However, its wide-ranging application is hindered by specialized, costly equipment and consumables. Herein, a ready-to-use lipid nanoparticle (RULNP)… read more here.
Keywords: nucleic acid; technology; delivery; use lipid ... See more keywords
Brain Nucleic Acid Delivery and Genome Editing via Focused Ultrasound-Mediated Blood-Brain Barrier Opening and Long-Circulating Nanoparticles.
Sign Up to like & getrecommendations! Published in 2024 at "ACS nano"
DOI: 10.1021/acsnano.4c05270
Abstract: We introduce a two-pronged strategy comprising focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening and long-circulating biodegradable nanoparticles (NPs) for systemic delivery of nucleic acids to the brain. Biodegradable poly(β-amino ester) polymer-based NPs were engineered to… read more here.
Keywords: nucleic acid; brain; long circulating; opening long ... See more keywords
Optimizing Nucleic Acid Delivery Systems through Barcode Technology.
Sign Up to like & getrecommendations! Published in 2024 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.3c00602
Abstract: Conventional biological experiments often focus on in vitro assays because of the inherent limitations when handling multiple variables in vivo, including labor-intensive and time-consuming procedures. Often only a subset of samples demonstrating significant efficacy in… read more here.
Keywords: nucleic acid; barcode; optimizing nucleic; delivery systems ... See more keywords
Length-Controlled Nanofiber Micelleplexes as Efficient Nucleic Acid Delivery Vehicles.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c06695
Abstract: Micelleplexes show great promise as effective polymeric delivery systems for nucleic acids. Although studies have shown that spherical micelleplexes can exhibit superior cellular transfection to polyplexes, to date there has been no report on the… read more here.
Keywords: delivery vehicles; microscopy; nanofiber micelleplexes; nucleic acid ... See more keywords
Improvement of ascorbic acid delivery into human skin via hyaluronic acid-coated niosomes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Microencapsulation"
DOI: 10.1080/02652048.2022.2135783
Abstract: Abstract Hyaluronic acid (HA) as a covering agent was incorporated into the ascorbic acid (AA)-niosomes to improve the performance of AA delivery systems into the skin. The preparation method: Thin film hydration. Characterisation tests: Field… read more here.
Keywords: improvement ascorbic; ascorbic acid; acid; hyaluronic acid ... See more keywords
Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002105
Abstract: The promise of therapeutic nucleic acids has long been tempered by difficulty in overcoming biological barriers to their delivery. The past two decades have seen the development of ionizable lipid nanoparticles as a vehicle for… read more here.
Keywords: overcoming biological; delivery; nucleic acid; biological barriers ... See more keywords
Targeting Accessories to the Crime: Nanoparticle Nucleic Acid Delivery to the Tumor Microenvironment
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.00307
Abstract: Nucleic acid delivery for cancer holds extraordinary promise. Increasing expression of tumor suppressor genes or inhibition of oncogenes in cancer cells has important therapeutic potential. However, several barriers impair progress in cancer gene delivery. These… read more here.
Keywords: acid delivery; delivery; cancer cells; cancer ... See more keywords