PAQR3 augments amino acid deprivation-induced autophagy by inhibiting mTORC1 signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.02.017
Abstract: Amino acids are the key activators of the mTOR complex 1 (mTORC1, mainly composed of mTOR, Raptor and mLST8) required for cell growth and proliferation. On the other hand, deprivation of amino acids induces autophagy… read more here.
Keywords: acid deprivation; paqr3; amino acid; mtorc1 signaling ... See more keywords
Predictive markers for efficiency of the amino-acid deprivation therapies in cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.1035356
Abstract: Amino acid deprivation therapy (AADT) is a promising strategy for developing novel anticancer treatments, based on variations in metabolism of healthy and malignant cells. L-asparaginase was the first amino acid-degrading enzyme that received FDA approval… read more here.
Keywords: acid deprivation; amino acid; medicine; cancer ... See more keywords