Lipid-based Nanocarriers Enabled Oral Delivery of Oleanolic Acid Derivative DKS26 for Diabetes Management.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300639
Abstract: Oleanolic acid (OA, (3β)-3-hydroxy-oleanol-12-en-28-oic acid) derivative DKS26 has hypolipidemic, islet and hepatoprotective effects. However, high lipophilicity and low water solubility of DKS26 led to its extremely low oral bioavailability. Herein, lipid-based nanocarriers, including lipid nanodiscs… read more here.
Keywords: dks26; lipid based; acid derivative; based nanocarriers ... See more keywords
Microfluidic Fabrication of Physically Assembled Nanogels and Micrometric Fibers by Using a Hyaluronic Acid Derivative
Sign Up to like & getrecommendations! Published in 2017 at "Macromolecular Materials and Engineering"
DOI: 10.1002/mame.201700265
Abstract: The employ of a hyaluronic acid (HA) derivative, bearing octadecyl (C18) and ethylenediamine (EDA) groups, for microfluidic fabrication of nanogels and microfibers is reported in this study. Two HA-EDA-C18 derivatives (125 and 320 kDa) having… read more here.
Keywords: acid derivative; fabrication; hyaluronic acid; microfluidic fabrication ... See more keywords
A New Hopantenic Acid Derivative from the Rhizomes of Heterosmilax japonica
Sign Up to like & getrecommendations! Published in 2018 at "Chemistry of Natural Compounds"
DOI: 10.1007/s10600-018-2569-7
Abstract: A new hopantenic acid derivative, (R)-methyl-4-(2,4-dihydroxy-3,3-dimethylbutanamido)butanoate (1), was isolated from the rhizomes of Heterosmilax japonica Kunth, together with three known compounds, (3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (2), daucosterol (3), and ethyl-β-D-xylobioside (4). The structure of 1 was determined… read more here.
Keywords: acid derivative; hopantenic acid; rhizomes heterosmilax; heterosmilax japonica ... See more keywords
A Nitroalkene Benzoic Acid Derivative Targets Reactive Microglia and Prolongs Survival in an Inherited Model of ALS via NF-κB Inhibition
Sign Up to like & getrecommendations! Published in 2020 at "Neurotherapeutics"
DOI: 10.1007/s13311-020-00953-z
Abstract: Motor neuron degeneration and neuroinflammation are the most striking pathological features of amyotrophic lateral sclerosis (ALS). ALS currently has no cure and approved drugs have only a modest clinically therapeutic effect in patients. Drugs targeting… read more here.
Keywords: acid derivative; inhibition; benzoic acid; motor ... See more keywords
Improvements in self-curing composites.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in medical sciences"
DOI: 10.1016/j.advms.2017.04.006
Abstract: PURPOSE The purpose of this study was to test the influence of a barbituric acid derivative acting as a catalyst and small amounts of pyrolytic silica in acrylic resins on color stability, solubility and sorption… read more here.
Keywords: acid derivative; barbituric acid; powder; sorption ... See more keywords
Modelling studies of enantioselective extraction of an amino acid derivative in slug flow capillary microreactors
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2018.08.006
Abstract: Abstract This work shows that enantioselective liquid–liquid extraction in microreactors is attractive for chiral separation. A precise control over the residence time in microreactors results in high enantiopurities and low host inventories. Mathematical modelling has… read more here.
Keywords: extraction; amino acid; acid derivative; slug flow ... See more keywords
A novel Gallic acid derivative attenuates BLM‐induced pulmonary fibrosis in mice
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.08.024
Abstract: ABSTRACT Idiopathic Pulmonary fibrosis is a disease with high morbidity and mortality. Therefore, the development of new drugs is imperative. Gallic acid derivative is a derivative of Gallic acid that can be extracted from Chinese… read more here.
Keywords: blm induced; pulmonary fibrosis; acid derivative; gallic acid ... See more keywords
Suzuki-Miyaura cross-coupling reaction of monohalopyridines and l-aspartic acid derivative
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.11.038
Abstract: Abstract Suzuki-Miyaura cross-coupling reaction of halogenated pyridines and a borated l -aspartic acid derivative was conducted. The reactivity of chloro-, bromo-, and iodo-pyridines with substituents at the C2, C3, and C4 positions was investigated. Electron… read more here.
Keywords: aspartic acid; acid derivative; miyaura cross; coupling reaction ... See more keywords
Structure analysis of a phenylpyrazole carboxylic acid derivative crystallizing with three molecules in the asymmetric unit (Z′ = 3) using X-ray powder diffraction
Sign Up to like & getrecommendations! Published in 2019 at "Powder Diffraction"
DOI: 10.1017/s0885715619000289
Abstract: Crystal structure analysis of a pyrazole carboxylic acid derivative, 5-(trifluoromethyl)-1-phenyl-1H-pyrazole-4-carboxylic acid (1) has been carried out from laboratory powder X-ray diffraction data. The crystal packing in the pyrazole carboxylic acid derivative exhibits an interplay of… read more here.
Keywords: carboxylic acid; acid derivative; diffraction; pyrazole carboxylic ... See more keywords
Adsorption Characteristics of Carbon Dioxide Gas on a Solid Acid Derivative of β-Cyclodextrin
Sign Up to like & getrecommendations! Published in 2017 at "Energy & Fuels"
DOI: 10.1021/acs.energyfuels.6b03167
Abstract: A solid acid derivative of β-cyclodextrin was synthesized as an adsorbent for CO2 capture. The adsorption characteristics, such as adsorption capacity, selectivity, and uptake rate, under different temperatures and gas pressures were analyzed. The results… read more here.
Keywords: solid acid; adsorption; acid derivative; derivative cyclodextrin ... See more keywords
Bioinspired Nanocomplexes Comprising Phenolic Acid Derivative and Human Serum Albumin for Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c03763
Abstract: Inspired by the natural phenomenon of phenolic-protein interactions, we translate this "naturally evolved interaction" to a "phenolic acid derivative based albumin bound" technology, through the synthesis of phenolic acid derivatives comprising a therapeutic cargo linked… read more here.
Keywords: phenolic acid; nanocomplexes comprising; acid derivative; bioinspired nanocomplexes ... See more keywords