Identification and characterization of Δ12 and Δ12/Δ15 bifunctional fatty acid desaturases in the oleaginous yeast Lipomyces starkeyi
Sign Up to like & getrecommendations! Published in 2018 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-018-9345-2
Abstract: Fatty acid desaturases play vital roles in the synthesis of unsaturated fatty acids. In this study, Δ12 and Δ12/Δ15 fatty acid desaturases of the oleaginous yeast Lipomyces starkeyi, termed LsFad2 and LsFad3, respectively, were identified… read more here.
Keywords: oleaginous yeast; fatty acid; desaturases oleaginous; linoleic acid ... See more keywords
Three, two, one yeast fatty acid desaturases: regulation and function
Sign Up to like & getrecommendations! Published in 2017 at "World Journal of Microbiology and Biotechnology"
DOI: 10.1007/s11274-017-2257-y
Abstract: Fatty acid composition of biological membranes functionally adapts to environmental conditions by changing its composition through the activity of lipid biosynthetic enzymes, including the fatty acid desaturases. Three major desaturases are present in yeasts, responsible… read more here.
Keywords: three two; fatty acid; yeast; acid desaturases ... See more keywords
Biosynthesis of Polyunsaturated Fatty Acids in the Razor Clam Sinonovacula constricta: Characterization of Δ5 and Δ6 Fatty Acid Desaturases.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.8b00968
Abstract: To investigate the endogenous long-chain polyunsaturated fatty acid (LC-PUFA) biosynthetic ability in Sinonovacula constricta, fatty acid desaturases (Fads) of this bivalve, namely, Scfad5a, Scfad5b, and Scfad6, were cloned and characterized in the current study. Meanwhile,… read more here.
Keywords: polyunsaturated fatty; constricta; fatty acid; fatty acids ... See more keywords
Acinetobacter baumannii Fatty Acid Desaturases Facilitate Survival in Distinct Environments.
Sign Up to like & getrecommendations! Published in 2021 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.1c00192
Abstract: Maintaining optimal fluidity is essential to ensure adequate membrane structure and function under different environmental conditions. We apply integrated molecular approaches to characterize two desaturases (DesA and DesB) and define their specific roles in unsaturated… read more here.
Keywords: fatty acid; desaturases facilitate; acid desaturases; acinetobacter baumannii ... See more keywords
Catalytic mechanisms underlying fungal fatty acid desaturases activities.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in biotechnology"
DOI: 10.1080/07388551.2022.2063106
Abstract: Polyunsaturated fatty acids (PUFAs) have beneficial roles in a variety of human pathologies and disorders. Owing to the limited source of PUFAs in animals and plants, microorganisms, especially fungi, have become a new source of… read more here.
Keywords: fads proteins; acid desaturases; mechanisms underlying; catalytic mechanisms ... See more keywords
Genetic Silencing of Fatty Acid Desaturases Modulates α-Synuclein Toxicity and Neuronal Loss in Parkinson-Like Models of C. elegans
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2019.00207
Abstract: The molecular basis of Parkinson’s disease (PD) is currently unknown. There is increasing evidence that fat metabolism is at the crossroad of key molecular pathways associated with the pathophysiology of PD. Fatty acid desaturases catalyze… read more here.
Keywords: like models; parkinson; fatty acid; genetic silencing ... See more keywords
A near complete genome assembly of chia assists in identification of key fatty acid desaturases in developing seeds
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2023.1102715
Abstract: Chia is an annual crop whose seeds have the highest content of α-linolenic acid (ALA) of any plant species. We generated a high-quality assembly of the chia genome using circular consensus sequencing of PacBio. The… read more here.
Keywords: acid desaturases; acid; assembly chia; seed ... See more keywords
Identification of Fatty Acid Desaturases in Maize and Their Differential Responses to Low and High Temperature
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DOI: 10.3390/genes10060445
Abstract: Plant fatty acid desaturases (FADs) catalyze the desaturation of fatty acids in various forms and play important roles in regulating fatty acid composition and maintaining membrane fluidity under temperature stress. A total of 30 FADs… read more here.
Keywords: temperature; fatty acid; identification fatty; stress ... See more keywords
Therapy-Resistant Acute Myeloid Leukemia Stem Cells Are Resensitized to Venetoclax + Azacitidine by Targeting Fatty Acid Desaturases 1 and 2
Sign Up to like & getrecommendations! Published in 2023 at "Metabolites"
DOI: 10.3390/metabo13040467
Abstract: Recent advances in targeting leukemic stem cells (LSCs) using venetoclax with azacitidine (ven + aza) has significantly improved outcomes for de novo acute myeloid leukemia (AML) patients. However, patients who relapse after traditional chemotherapy are… read more here.
Keywords: acid desaturases; acute myeloid; venetoclax azacitidine; stem cells ... See more keywords