Role of fatty acid elongase Elovl6 in the regulation of energy metabolism and pathophysiological significance in diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Diabetology International"
DOI: 10.1007/s13340-020-00481-3
Abstract: Type 2 diabetes mellitus (T2DM) is an expanding epidemic, closely linked to obesity. Peripheral insulin resistance and impaired insulin secretion remain the core defects in T2DM. Despite significant advances in unraveling the underlying these defects,… read more here.
Keywords: insulin; acid elongase; fatty acid; insulin resistance ... See more keywords
Δ6 Fatty Acid Elongase is Involved in Eicosapentaenoic Acid Biosynthesis Via the ω6 Pathway in the Marine Alga Nannochloropsis oceanica.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c04192
Abstract: Nannochloropsis oceanica represents a promising sunlight-driven alga for producing eicosapentaenoic acid (EPA, 20:5Δ5,8,11,14,17), a value-added very long-chain polyunsaturated fatty acid (VLC-PUFA). Here, we unraveled the function and roles of a Δ6 fatty acid elongase (NoΔ6-FAE)… read more here.
Keywords: eicosapentaenoic acid; nannochloropsis oceanica; acid elongase; fatty acid ... See more keywords
Incomplete Elongation of Ultra-long-chain Polyunsaturated Acyl-CoAs by the Fatty Acid Elongase ELOVL4 in Spinocerebellar Ataxia Type 34
Sign Up to like & getrecommendations! Published in 2023 at "Molecular and Cellular Biology"
DOI: 10.1080/10985549.2023.2169563
Abstract: Abstract Spinocerebellar ataxias (SCAs) are autosomal dominant diseases characterized by cerebellar atrophy and ataxia. The SCA subtype SCA34 is caused by specific mutations in the gene ELOVL4, which encodes a fatty acid (FA) elongase that… read more here.
Keywords: long chain; ultra long; acid elongase; incomplete elongation ... See more keywords
The very-long-chain fatty acid elongase Elo2 rescues lethal defects associated with loss of the nuclear barrier function in fission yeast cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.229021
Abstract: ABSTRACT In eukaryotic cells, chromosomes are confined to the nucleus, which is compartmentalized by the nuclear membranes; these are continuous with the endoplasmic reticulum membranes. Maintaining the homeostasis of these membranes is an important cellular… read more here.
Keywords: acid elongase; fatty acid; nuclear membrane; long chain ... See more keywords
Tackling functional redundancy of Arabidopsis fatty acid elongase complexes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2023.1107333
Abstract: Very-long-chain fatty acids (VLCFA) are precursors for various lipids playing important physiological and structural roles in plants. Throughout plant tissues, VLCFA are present in multiple lipid classes essential for membrane homeostasis, and also stored in… read more here.
Keywords: redundancy; fae complexes; acid elongase; fatty acid ... See more keywords