Hydrophilic Azide-Containing Amino Acid to Enhance the Solubility of Peptides for SPAAC Reactions.
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DOI: 10.1021/acs.orglett.2c02906
Abstract: We report a new positively charged azidoamino acid for strain-promoted azide-alkyne cycloaddition (SPAAC) applications that overcomes possible solubility limitations of commonly used azidolysine, especially in systems with numerous ligation sites. The residue is easily synthesized,… read more here.
Keywords: acid enhance; containing amino; solubility; amino acid ... See more keywords