Discovery and Optimization of Novel Nonbile Acid FXR Agonists as Preclinical Candidates for the Treatment of Inflammatory Bowel Disease.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c02304
Abstract: Inflammatory bowel disease (IBD) is a multifactorial chronic inflammation of the intestine and has become a global public health concern. A farnesoid X receptor (FXR) was recently reported to play a key role in hepatic-intestinal… read more here.
Keywords: fxr agonists; fxr; acid fxr; bowel disease ... See more keywords
Molecular Basis of Bile Acid-FXR-FGF15/19 Signaling Axis
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DOI: 10.3390/ijms23116046
Abstract: Bile acids (BAs) are a group of amphiphilic molecules consisting of a rigid steroid core attached to a hydroxyl group with a varying number, position, and orientation, and a hydrophilic side chain. While BAs act… read more here.
Keywords: acid fxr; fxr fgf15; basis bile; molecular basis ... See more keywords