Enantioselective binding of carvedilol to human serum albumin and alpha-1-acid glycoprotein.
Sign Up to like & getrecommendations! Published in 2023 at "Chirality"
DOI: 10.1002/chir.23595
Abstract: Carvedilol, a highly protein-bound beta-blocker, is used in therapy as a racemic mixture of its two enantiomers that exhibit different pharmacological activity. The aim of this study was to evaluate the stereoselective nature of its… read more here.
Keywords: carvedilol; acid glycoprotein; alpha acid;
Pharmacokinetic and Pharmacodynamic Considerations for Drugs Binding to Alpha-1-Acid Glycoprotein
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutical Research"
DOI: 10.1007/s11095-018-2551-x
Abstract: According to the free drug hypothesis only the unbound drug is available to act at physiological sites of action, and as such the importance of plasma protein binding primarily resides in its impact on pharmacokinetics… read more here.
Keywords: alpha acid; acid glycoprotein; drug; pharmacodynamic considerations ... See more keywords
Improving Pediatric Protein Binding Estimates: An Evaluation of α1-Acid Glycoprotein Maturation in Healthy and Infected Subjects
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-017-0576-7
Abstract: BackgroundDifferences in plasma protein levels observed between children and adults can alter the extent of xenobiotic binding in plasma, resulting in divergent patterns of exposure.ObjectiveThis study aims to quantify the ontogeny of α1-acid glycoprotein in… read more here.
Keywords: fold error; acid glycoprotein; average fold; infected subjects ... See more keywords
The bovine acute phase protein α1-acid glycoprotein (AGP) can disrupt Staphylococcus aureus biofilm.
Sign Up to like & getrecommendations! Published in 2019 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2019.06.007
Abstract: Staphylococcus aureus biofilm-related infections are of clinical concern due to the capability of bacterial colonies to adapt to a hostile environment. The present study investigated the capability of the acute phase protein alpha 1-acid glycoprotein… read more here.
Keywords: acute phase; staphylococcus aureus; acid glycoprotein; aureus biofilm ... See more keywords
Interaction of Aripiprazole with Human α1-Acid Glycoprotein.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2019.09.003
Abstract: We recently reported that aripiprazole binds strongly to human albumin. In continuing our investigations, we investigated the mechanism responsible for the binding and the related interactions of aripiprazole with α1-acid glycoprotein (AGP). The extrinsic Cotton… read more here.
Keywords: acid glycoprotein; interaction aripiprazole; human acid; albumin ... See more keywords
Hydrolase Activity of the Genetic Variants of Human Alpha-1-Acid Glycoprotein.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00614
Abstract: In human plasma, the main agent of hydrolysis of the ester-type prodrug of levodopa, designated ONO-2160, is alpha-1-acid glycoprotein (AGP), which is a mixture of the F1*S and A variants at molar ratios of 3:1… read more here.
Keywords: ono 2160; acid glycoprotein; activity; hydrolysis ... See more keywords
Contribution of Phe112, Ser114, and Tyr115 to Drug-Binding Selectivity in the A Variant of α1-Acid Glycoprotein.
Sign Up to like & getrecommendations! Published in 2024 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.4c00428
Abstract: The plasma protein α1-acid glycoprotein (AGP) primarily affects the pharmacokinetics of basic drugs. There are two AGP variants in humans, A and F1*S, exhibiting distinct drug-binding selectivity. Elucidation of the drug-binding selectivity of human AGP… read more here.
Keywords: binding selectivity; acid glycoprotein; drug; phe112 ser114 ... See more keywords
Alpha-1-acid glycoprotein and its potential impact on local anesthetic dose in neonates.
Sign Up to like & getrecommendations! Published in 2023 at "Paediatric anaesthesia"
DOI: 10.1111/pan.14672
Abstract: Alpha‐1‐acid glycoprotein is an acute‐phase protein with a high affinity for amide local anesthetics. Compared to adults, neonates have lower concentrations of this glycoprotein in plasma, and are therefore at higher risk of developing local… read more here.
Keywords: glycoprotein potential; potential impact; local anesthetic; impact local ... See more keywords
Cat alpha-1-acid glycoprotein enzyme-linked immunosorbent assay: performance characteristics and reference intervals
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Feline Medicine and Surgery"
DOI: 10.1177/1098612x231162836
Abstract: Objectives The aim of this study was to evaluate performance of a feline-specific ELISA for the measurement of alpha-1-acid glycoprotein (AGP) and to establish a reference interval (RI). Methods Surplus serum samples with low (~200 µg/ml),… read more here.
Keywords: acid glycoprotein; alpha acid; performance; agp concentrations ... See more keywords
The association between fat distribution and α1-acid glycoprotein levels among adult females in the United States
Sign Up to like & getrecommendations! Published in 2024 at "Lipids in Health and Disease"
DOI: 10.1186/s12944-024-02223-9
Abstract: Background Visceral fat accumulation and obesity-induced chronic inflammation have been proposed as early markers for multiple disease states, especially in women. Nevertheless, the potential impact of fat distribution on α1-acid glycoprotein(AGP), a marker of inflammation,… read more here.
Keywords: agp; distribution; acid glycoprotein; percent fat ... See more keywords
Alpha-1 Acid Glycoprotein as a Biomarker for Subclinical Illness and Altered Drug Binding in Rats.
Sign Up to like & getrecommendations! Published in 2021 at "Comparative medicine"
DOI: 10.30802/aalas-cm-20-000088
Abstract: Alpha-1 acid glycoprotein (AGP) is a significant drug binding acute phase protein that is present in rats. AGP levels areknown to increase during tissue injury, cancer and infection. Accordingly, when determining effective drug ranges and… read more here.
Keywords: alpha acid; agp; drug binding; drug ... See more keywords