Acyclic (S)-glycol nucleic acid (S-GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency
Sign Up to like & getrecommendations! Published in 2023 at "RNA"
DOI: 10.1261/rna.079526.122
Abstract: Glycol nucleic acid (GNA) is an acyclic nucleic acid analog connected via phosphodiester bonds. Crystal structures of RNA–GNA chimeric duplexes indicated that nucleotides of the right-handed (S)-GNA were better accommodated in the right-handed RNA duplex… read more here.
Keywords: acid gna; glycol nucleic; gna; nucleic acid ... See more keywords